Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis



Dendritic cells are the most efficient antigen-presenting cells. They capture, process and present antigens to T cells, thus initiating specific immune responses. Taking into account this capability, dendritic cells have been proposed as therapeutic agents against tumors. In recent years other properties of dendritic cells have surfaced. In particular, dendritic cells have been shown to have immunosuppressive properties in some settings and were also capable of inducing proliferation of regulatory T cells. Moreover, it has been shown that dendritic cells are able to generate angiogenic factors and might be able to participate in the angiogenic process. Thus, for tumor therapeutic purposes, further studies on the biology of dendritic cells are necessary in order to generate cells with optimized immunogenic properties, but avoiding a pro-angiogenic profile.


Vascular Endothelial Growth Factor Dendritic Cell Specific Immune Response Plasmacytoid Dendritic Cell Immature Dendritic Cell 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Gynecologic Oncology, Center for Research on Ovarian CancerUniversity of PennsylvaniaPhiladelphiaUSA

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