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Stress, Immunity and Dendritic Cells in Cancer

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Dendritic Cells in Cancer

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Abstract

The literature on stress and immunity clearly demonstrates that stress exposure modifies certain aspects of immune function. While stressful experiences and stress-associated molecules have well-documented effects on the activity of lymphocytes, stress exposure may disrupt processes that occur earlier in the immune response. Stress-induced alterations in immune function may, in part, result from changes in the development and/or function of cells involved in the initiation of the response, namely dendritic cells. Although the literature is relatively limited, the findings suggest that stress-associated hormones and neuropeptides can modulate maturation and migration of dendritic cells. The present chapter concentrates on stress-related alterations in dendritic cell function and the potential relevance of psychological factors to the progression of cancer and to the effectiveness of therapeutic treatments.

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Acknowledgments

Support contributed by grants MH60706, NIEHS P30 ES05022 and NIEHS Graduate Training grant 5T32 E507148.

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  1. Department of Psychology, Rutgers University, Piscatway, NJ 08854, USA

    Alexander W. Kusnecov

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    Kohman, R., Kusnecov, A.W. (2009). Stress, Immunity and Dendritic Cells in Cancer. In: Salter, R., Shurin, M. (eds) Dendritic Cells in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88611-4_13

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