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Relief of Labor Pain by Systemic Medications and Inhalational Agents

  • Sanjay Datta
  • Bhavani Shankar Kodali
  • Scott Segal
Chapter

Abstract

Systemic medications have been used exclusively or in association with psychoanalgesia for relief of labor pain during both the first and second stages of labor. These drugs can be classified into several categories.

Keywords

Nitrous Oxide Epidural Analgesia Labor Pain Labor Analgesia Lockout Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Way WL, Costley EC, Leongway E. Respiratory sensitivity of the newborn infant to meperidine and morphine. Clin Pharmacol Ther. 1965;6:454–461.PubMedGoogle Scholar
  2. 2.
    Olofsson C, Ekblom A, Ekman-Ordeberg G, Hjelm A, Irestedt L. Lack of analgesic effect of systemically administered morphine or pethidine on labour pain. Br J Obstet Gynaecol. 1996;103(10):968–972.PubMedGoogle Scholar
  3. 3.
    Shnider SM, Way WL, Lord MJ. Rate of appearance and disappearance of meperidine in fetal blood after administration of narcotic to the mother. Anesthesiology. 1966;17:227.CrossRefGoogle Scholar
  4. 4.
    Shnider SM, Moya F. Effects of meperidine on the newborn infant. Am J Obstet Gynecol. 1964;89:1009–1015.PubMedGoogle Scholar
  5. 5.
    Kuhnert BR, Kuhnert PM, Tu AS, Lin DC. Meperidine and normeperidine levels following meperidine administration during labor. II. Fetus and neonate. Am J Obstet Gynecol. 1979;133(8):909–914.PubMedGoogle Scholar
  6. 6.
    Sosa CG, Buekens P, Hughes JM, et al. Effect of pethidine administered during the first stage of labor on the acid–base status at birth. Eur J Obstet Gynecol Reprod Biol. 2006;129(2):135–139.CrossRefPubMedGoogle Scholar
  7. 7.
    Wittels B, Scott DT, Sinatra RS. Exogenous opioids in human breast milk and acute neonatal neurobehavior: a preliminary study. Anesthesiology. 1990;73(5):864–869.CrossRefPubMedGoogle Scholar
  8. 8.
    Halpern SH, Muir H, Breen TW, et al. A multicenter randomized controlled trial comparing patient-controlled epidural with intravenous analgesia for pain relief in labor. Anesth Analg. 2004;99(5):1532–1538, table of contents.CrossRefPubMedGoogle Scholar
  9. 9.
    Eisele JH, Wright R, Rogge P. Newborn and maternal fentanyl levels at cesarean section. Anesth Anal. 1982;61:179.Google Scholar
  10. 10.
    Balki M, Kasodekar S, Dhumne S, Bernstein P, Carvalho JC. Remifentanil patient-controlled analgesia for labour: optimizing drug delivery regimens. Can J Anaesth. 2007;54(8):626–633.CrossRefPubMedGoogle Scholar
  11. 11.
    Volmanen P, Sarvela J, Akural EI, Raudaskoski T, Korttila K, Alahuhta S. Intravenous remifentanil vs. epidural levobupivacaine with fentanyl for pain relief in early labour: a randomised, controlled, double-blinded study. Acta Anaesthesiol Scand. 2008;52(2):249–255.CrossRefPubMedGoogle Scholar
  12. 12.
    Dailey PA, Baysinger CL, Levinson G, Shnider SM. Neurobehavioral testing of the newborn infant. Effects of obstetric anesthesia. Clin Perinatol. 1982;9(1):191–214.PubMedGoogle Scholar
  13. 13.
    Roblin SH, Wright R, Shnider SM, et al. Diazepam during cesarean section – effects on neonatal Apgar scores, acid–base status, neurobehavioral assessment and maternal and fetal plasma norepinephrine levels (abstract). American Society of Anesthesiologists Annual Meeting, New Orleans. 1977:449.Google Scholar
  14. 14.
    Janeczko GF, el-Etr AA, Younes S. Low-dose ketamine anesthesia for obstetrical delivery. Anesth Analg. 1974;53(6):828–831.CrossRefPubMedGoogle Scholar
  15. 15.
    Douglas MJ, Levinson G. Systemic medication for labor and delivery. 4th ed. Philadelphia: Lippincot William and Wilkins; 2001.Google Scholar
  16. 16.
    Marx GF, Hwang HS, Chandra P. Postpartum uterine pressures with different doses of ketamine. Anesthesiology. 1979;50(2):163–166.CrossRefPubMedGoogle Scholar
  17. 17.
    Hatjis CG, Meis PJ. Sinusoidal fetal heart rate pattern associated with butorphanol administration. Obstet Gynecol. 1986;67(3):377–380.PubMedGoogle Scholar
  18. 18.
    Frank M, McAteer EJ, Cattermole R, Loughnan B, Stafford LB, Hitchcock AM. Nalbuphine for obstetric analgesia. A comparison of nalbuphine with pethidine for pain relief in labour when administered by patient-controlled analgesia (PCA). Anaesthesia. 1987;42(7):697–703.CrossRefPubMedGoogle Scholar
  19. 19.
    Nicolle E, Devillier P, Delanoy B, Durand C, Bessard G. Therapeutic monitoring of nalbuphine: transplacental transfer and estimated pharmacokinetics in the neonate. Eur J Clin Pharmacol. 1996;49(6):485–489.CrossRefPubMedGoogle Scholar
  20. 20.
    Oyston J. Obstetrical anaesthesia in Ontario. Can J Anaesth. 1995;42(12):1117–1125.CrossRefPubMedGoogle Scholar
  21. 21.
    Brownridge P. Treatment options for the relief of pain during childbirth. Drugs. 1991;41(1):69–80.CrossRefPubMedGoogle Scholar
  22. 22.
    Abboud TK, Gangolly J, Mosaad P, Crowell D. Isoflurane in obstetrics. Anesth Analg. 1989;68(3):388–391.CrossRefPubMedGoogle Scholar
  23. 23.
    Abboud TK, Shnider SM, Wright RG, et al. Enflurane analgesia in obstetrics. Anesth Analg. 1981;60(3):133–137.CrossRefPubMedGoogle Scholar
  24. 24.
    Yeo ST, Holdcroft A, Yentis SM, Stewart A, Bassett P. Analgesia with sevoflurane during labour: ii. Sevoflurane compared with Entonox for labour analgesia. Br J Anaesth. 2007;98(1):110–115.CrossRefPubMedGoogle Scholar
  25. 25.
    Abboud TK, Swart F, Zhu J, Donovan MM, Peres Da Silva E, Yakal K. Desflurane analgesia for vaginal delivery. Acta Anaesthesiol Scand. 1995;39(2):259–261.CrossRefPubMedGoogle Scholar
  26. 26.
    Munson ES, Maier WR, Caton D. Effects of halothane, cyclopropane and nitrous oxide on isolated human uterine muscle. J Obstet Gynaecol Br Commonw. 1969;76(1):27–33.PubMedGoogle Scholar
  27. 27.
    Kumarasinghe N, Harpin R, Stewart AW. Blood loss during suction termination of pregnancy with two different anaesthetic techniques. Anaesth Intensive Care. 1997;25(1):48–50.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sanjay Datta
    • 1
    • 2
  • Bhavani Shankar Kodali
    • 1
    • 2
  • Scott Segal
    • 1
    • 2
  1. 1.Brigham & Women’s HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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