Drug Interactions and Obstetric Anesthesia

  • Sanjay Datta
  • Bhavani Shankar Kodali
  • Scott Segal


Often, parturients may receive antibiotics for various disease processes. This is particularly observed in high risk management labor and delivery units. Most of the antibiotics will prolong the effect of nondepolarizing muscle relaxants, but prolongation of depolarizing muscle relaxants has also been observed (Table 4-1).1,2 The table cites the example of d-tubocurarine; however, the duration of action of presently used muscle relaxants including vecuronium and rocuronium are also prolonged by antibiotics.35 The mechanism of this phenomenon is unknown. Antagonism of this action by neostigmine and pyridostigmine is found to be unpredictable; however, neuromuscular blockade from antibiotics could be reversed predictably by 4-aminopyridine.2 An interesting observation made in rats that may have clinical bearing is that the neuromuscular block produced by a combination of neuromuscular-blocking drugs and antibiotics could be prolonged in the presence of local anesthetic lidocaine.6


Antipsychotic Drug Regional Anesthesia Magnesium Sulfate Minimum Alveolar Concentration Inhalational Anesthetic 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sanjay Datta
    • 1
    • 2
  • Bhavani Shankar Kodali
    • 1
    • 2
  • Scott Segal
    • 1
    • 2
  1. 1.Brigham & Women’s HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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