Drug Selection for Intrathecal Drug Delivery
The use of intrathecal agents to treat pain and other diseases such as spasticity is based on the principle that delivering drugs directly to the cerebral spinal fluid (CSF) bypasses the first-pass effect and results in a higher degree of effectiveness when compared with other routes of delivery such as the oral or transdermal approach. The result of this improvement in delivery is a favorable equipotent dosing comparison. It also results in less impact on the end organs and overall reduced systemic drug exposure.
KeywordsCerebral Spinal Fluid Opioid Therapy Inflammatory Mass Intrathecal Therapy Risk Avoidance
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