• Gloria F. Graham


The history of cryosurgery in dermatology dates back to the 1890s, when White, a New York dermatologist, dipped a cotton-tipped applicator into liquefied air in 1899 and successfully treated warts, keratoses, and skin cancers.1 Torre2 and Zacarian3 both published their findings on the use of freezing for treating skin cancer in the mid-1960s. The Spillers first described its use with curettage and this is a technique that is often used today.


Skin Cancer Basal Cell Carcinoma Actinic Keratosis Freeze Time Actinic Cheilitis 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gloria F. Graham
    • 1
  1. 1.Department of DermatologyWake Forest University School of MedicineWinston-SalemUSA

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