Radiation Oncology in Skin Cancer Treatment
Radiation was first used to treat a patient with squamous cell carcinoma of the nose in 1900. Following the development of improved dermatologic and surgical techniques in the 1950s, the role for radiation in the treatment of skin cancer gradually decreased.1 However, there remain certain settings in which radiation offers advantages over other currently available modalities. The goals of this chapter are to review the current indications for the use of radiation in the treatment of skin cancer, the techniques commonly employed in modern radiotherapy, the role of radiation in the treatment of specific skin malignancies, and the complications that arise from the use of radiation to treat skin cancers.
KeywordsSkin Cancer Basal Cell Carcinoma Adjuvant Radiation Merkel Cell Carcinoma Mycosis Fungoides
Many thanks to William Morrison, M.D., for valuable discussions and to Sherry Garcia, M.P.A.S., PA-C for providing patient cases.
- 1.Wilson L, Panizzon RG. Radiation Treatment. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. 1st ed. London: Elsevier Ltd.; 2003:2185–2195.Google Scholar
- 5.Guadagnolo AB, Ang KK, Ballo MT. The Skin.In: Cox JD, Ang KK, eds. Radiation Oncology. 9th ed. Philadelphia: Mosby; In press.Google Scholar
- 8.Chao KS, Perez CA, Brady LW. Skin, Acquired immunodeficiency syndrome, and kaposi’s sarcoma. In: Chao KS, Perez CA, Brady LW, eds. Radiation Oncology: Management Decisions. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2002:111–121.Google Scholar
- 10.Perez CA, Lovett RD, Gerber R. Electron beam and x-rays in the treatment of epithelial skin cancer: dosimetric considerations and clinical results. In: Vaeth JM, Meyer JL, eds. Frontiers of Radiation Therapy And Oncology: The Role of High Energy Electrons in the Treatment of Cancer. Vol 25. Basel: S. Karger; 1991:90–106.Google Scholar
- 13.Wilder RB, Margolis LW. Skin cancer. In: Leibel SA, Phillips TL, eds. Textbook of Radiation Oncology. Philadelphia: WB Saunders; 1998:1165–1182.Google Scholar
- 20.Solan MJ, Brady LW, Binnick SA, Fitzpatrick PJ. Skin. In: Perez CA, Brady LW, eds. Principles and Practice of Radiation Oncology. 3rd ed. Philadelphia: Lippincott-Raven Publishers; 1998:723–744.Google Scholar
- 28.Ballo MT, Ang KK. Radiotherapy for cutaneous malignant melanoma: rationale and indications. Oncology (Williston Park). Jan 2004;18(1):99–107; discussion 107–110, 113–104.Google Scholar
- 32.Pacella J, Ashby M, Ainslie J, Minty C. The role of radiotherapy in the management of primary cutaneous neuroendocrine tumors (Merkel cell or trabecular carcinoma): experience at the Peter MacCallum Cancer Institute (Melbourne, Australia). Int J Radiat Oncol Biol Phys. Jun 1988;14(6):1077–1084.CrossRefPubMedGoogle Scholar
- 34.Voutsadakis IA, Bruckner HW. Eccrine sweat gland carcinoma: a case report and review of diagnosis and treatment. Conn Med. May 2000;64(5):263–266.Google Scholar
- 37.Jones GW, Kacinski BM, Wilson LD, et al. Total skin electron radiation in the management of mycosis fungoides: consensus of the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Project Group. J Am Acad Dermatol. Sep 2002;47(3):364–370.CrossRefPubMedGoogle Scholar
- 43.Perkins JL, Liu Y, Mitby PA, et al. Nonmelanoma skin cancer in survivors of childhood and adolescent cancer: a report from the childhood cancer survivor study. J Clin Oncol. 2005;23:3733–3741.Google Scholar