Biopsy Techniques and Interpretation

  • Deborah F. MacFarlane
  • Ronald P. Rapini


The performance of a skin biopsy is an intrinsic part of the initial management of a patient suspected of having a skin cancer.1,2 This first chapter will therefore begin with a discussion of the various skin biopsy techniques most commonly used in the diagnosis of skin cancer and their clinical indications. This will be followed by a frank discussion of the interpretation of biopsy results. Discussion of other biopsy techniques such as curettage and sentinel lymph node biopsy will be dealt with elsewhere (Chapters 6 and 15, respectively).


Sentinel Lymph Node Biopsy Skin Cancer Biopsy Site Biopsy Technique Clopidogrel Bisulfate 
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  1. 1.
    Rapini RP. Obtaining a skin biopsy and interpreting the results. Dermatol Clin. 1994;12:83–91.PubMedGoogle Scholar
  2. 2.
    Olbricht S. Biopsy techniques and basic excisions. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. 2nd ed. London: Elsevier; 2008:2209–2225.Google Scholar
  3. 3.
    Stewart JH, Cole GW, Klein JA. Neutralized lidocaine with epinephrine for local anesthesia. J Dermatol Surg Oncol. 1989;15:1081–1083.PubMedGoogle Scholar
  4. 4.
    Armstrong RB, Nickhols J, Pachance J. Punch biopsy wounds treated with Monsel’s solution or a collagen matrix: a comparison of healing. Arch Dermatol. 1988;122:546–549.CrossRefGoogle Scholar
  5. 5.
    Ackerman B. Shave biopsies: the good and right, the bad and wrong. Am J Dermatopathol. 1983;5:211–212.CrossRefPubMedGoogle Scholar
  6. 6.
    Harvey DT, Fenske NA. The razor blade biopsy technique. Dermatol Surg. 1995;21:345–347.CrossRefPubMedGoogle Scholar
  7. 7.
    Silvers DN. The “lost” skin biopsy: how to prevent it. Cutis. 1999;64:355–356.PubMedGoogle Scholar
  8. 8.
    Ackerman AB. Biopsy why, where, when, how. J Dermatol Surg. 1975;1:21–23.PubMedGoogle Scholar
  9. 9.
    Eaglstein WH. Moist wound healing with occlusive dressings: a clinical focus. Dermatol Surg. 2001;27:175–181.CrossRefPubMedGoogle Scholar
  10. 10.
    Salopek TG, Slade J, Marghoob AA, et al. Management of cutaneous malignant melanoma by dermatologists of the American Academy of Dermatology. I. Survey of biopsy practices of pigmented lesions suspected as melanoma. J Am Acad Dermatol. 1995;33:441–450.CrossRefPubMedGoogle Scholar
  11. 11.
    Dunlavey E, Leshin B. The simple excision. Dermatol Clin. 1998;16:49–64.CrossRefPubMedGoogle Scholar
  12. 12.
    Zitelli JA. Tips for a better ellipse. J Am Acad Dermatol. 1990;2:101–103.CrossRefGoogle Scholar
  13. 13.
    Rapini RP. Comparison of methods for checking surgical margins. J Am Acad Dermatol. 1990;123:288–294.CrossRefGoogle Scholar
  14. 14.
    Rapini RP. Pitfalls of Mohs micrographic surgery. J Am Acad Dermatol. 1990;22:681–686.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Deborah F. MacFarlane
    • 1
  • Ronald P. Rapini
    • 2
  1. 1.Departments of Dermatology and Plastic SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of DermatologyUniversity of Texas Medical SchoolHoustonUSA

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