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Effect Modification

  • Bryan Kestenbaum
Chapter

Learning Objectives

  1. 1.

    Effect modification is present when the size of an association differs by another factor.

     
  2. 2.

    The presence of effect modification can suggest synergy between exposure variables.

     
  3. 3.

    Effect modification is a different concept from confounding; a particular characteristic can function as a confounder, an effect modifier, both, or neither in a given study.

     
  4. 4.

    The likelihood ratio test evaluates whether the size of an association is statistically different across two or more categories of another factor.

     
  5. 5.

    The p-value from the likelihood ratio test represents the probability of finding the observed difference in the size of an association across subgroups due to chance.

     

Keywords

Likelihood Ratio Test Effect Modification Laryngeal Cancer Heavy Alcohol Attributable Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. Jan 2005;36(1):62–65.CrossRefPubMedGoogle Scholar
  2. 42.
    Terry PD, Miller AB, Rohan TE. Obesity and colorectal cancer risk in women. Gut. Aug 2002;51(2):191–194.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.University of WashingtonSeattleUSA

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