Epigenetic Mechanisms of Ovarian Gene Regulation

  • Holly A. LaVoie

Epigenetics refers to alterations in gene function that are heritable between generations of cells or animals and that do not involve a change in the DNA sequence itself [1]. Such alterations occur at the level of chromatin and include post-translational modifications of histone tails and methylation of DNA. In a more narrow sense, epigenetics can be used to describe chromatin altering events within a single cell or groups of cells that leads to changes in gene function in response to hormones or growth factors. This chapter will briefly describe the most common epigenetic marks and review studies of chromatin alterations as they relate to gene function in cells of the developing ovarian follicle and corpus luteum.


Luteinizing Hormone Granulosa Cell Histone Modification Corpus Luteum Theca Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


24.6Glossary of Terms and Acronyms

Aurora kinases:

a family of serine/threonine kinases important for cell division


CREB-binding protein and related E1A binding protein p300


CCAAT enhancer binding protein beta


chromatin immunoprecipitation


corpus luteum


corepressor for RE1 silencing transcription factor (REST)


gene coding for P450scc


gene coding for cytochrome P450 17α-hydroxylase/17,20-lyase

DNMT1 and DNMT3:

DNA cytosine-5 methyltransferases 1 and 3


gene coding for c-Fos


family of transcription factors that contain a two-zinc-finger motif and bind to the DNA sequence (A/T)GATA(A/G)


an histone acetyltransferase


rat granulosa stable cell line


core histone 2A variant


histone acetyltransferases


histone deacetylases 1 and 2


histone deacetylases


histone methyltransferases


heterochromatin 1 protein


gene(s) coding for 3β-HSD


histone demethylases of the Jumonji family


histone demethylase of the Jumonji family


Kruppel-like factor 13


low-density lipoprotein


lysine specific demethylase 1


mitogen- and stress-activated protein kinases 1 and 2


Niemann-Pick C1 gene


nucleosome remodeling and deacetylase


p21-activated kinase-1


p300/CBP-associated factor


polycystic ovary syndrome


protein kinase A


phosphatase type 1


phosphatase type 2A


protein arginine methyltransferases


rat placental lactogen


ribosomal S6 kinase 2

SET domain:

a domain found in some lysine methyltransferases, derived from Drosophilia proteins designated suppressor of variegation, enhancer of zeste and trithorax


transcription factor steroidogenic factor 1, also termed NR5A1


a SWI independent corepressor found in complexes with HDACs


Sin3 family member A


nucleosome-remodeling ATPase

Sp1 and Sp3:

transcription factor specificity proteins 1 and 3


steroid receptor coactivator


gene coding for steroidogenic acute regulatory (STAR) protein


signal transducers and activators of transcription


SWItch proteins, part of chromatin remodeling ATPase complexes


an histone acetyltransferase


trichostatin A, an HDAC inhibitor


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Cell Biology and AnatomyUniversity of South Carolina School of MedicineColumbiaUSA

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