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Ovarian Endocrine Activity: Role of Follistatin, Activin, and Inhibin

  • Stella Campo
  • Nazareth Loreti
  • Luz Andreone
Chapter

The first evidence of a testicular non-steroidal factor able to regulate the activity of the pituitary gland was reported by Roy McCullagh in 1932 [1]. He observed that the administration of an aqueous testicular preparation to castrated rats was able to restore the physiological characteristics of pituitary cells that had been altered after castration. This bioactive factor was called “inhibin.” When FSH and LH were purified, standards were available and specific radioimmunoassays were developed to determine their levels in biological fluids. The application of these methodologies to patients with gonadal dysfunctions confirmed the existence of a gonadal regulatory mechanism specific for FSH secretion. In adult males with damaged seminiferous tubules epithelium, a marked increase of FSH levels, concomitantly with normal testosterone and LH levels, was reported [2]. Similar observations were described in pre-menopausal women, with elevated serum FSH levels and normal estradiol, during the follicular phase of the menstrual cycle [3].

Keywords

Granulosa Cell Corpus Luteum Follicular Fluid Follicular Phase Pubertal Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

22.9Glossary of Terms and Acronyms

AMH:

anti-Müllerian hormone, also termed MIS

FRP:

FSH releasing proteins

FSH:

follicle stimulating hormone

GnRH:

gonadotropin releasing hormone

hCG:

human chorionic gonadotropin

IGF-1:

insulin like growth factor-1

IVF:

in vitro fertilization

LH:

luteinizing hormone

MIS:

müllerian inhibiting substance

mRNA:

messenger RNA

RIA:

radioimmunoassay

RNA:

ribonucleic acid

TGF:

transforming growth factor

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Centro de Investigaciones EndocrinológicasHospital de Niños Ricardo GutiérrezBuenos AiresArgentina

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