Ovarian Endocrine Activity: Role of Follistatin, Activin, and Inhibin

  • Stella Campo
  • Nazareth Loreti
  • Luz Andreone

The first evidence of a testicular non-steroidal factor able to regulate the activity of the pituitary gland was reported by Roy McCullagh in 1932 [1]. He observed that the administration of an aqueous testicular preparation to castrated rats was able to restore the physiological characteristics of pituitary cells that had been altered after castration. This bioactive factor was called “inhibin.” When FSH and LH were purified, standards were available and specific radioimmunoassays were developed to determine their levels in biological fluids. The application of these methodologies to patients with gonadal dysfunctions confirmed the existence of a gonadal regulatory mechanism specific for FSH secretion. In adult males with damaged seminiferous tubules epithelium, a marked increase of FSH levels, concomitantly with normal testosterone and LH levels, was reported [2]. Similar observations were described in pre-menopausal women, with elevated serum FSH levels and normal estradiol, during the follicular phase of the menstrual cycle [3].


Granulosa Cell Corpus Luteum Follicular Fluid Follicular Phase Pubertal Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


22.9Glossary of Terms and Acronyms


anti-Müllerian hormone, also termed MIS


FSH releasing proteins


follicle stimulating hormone


gonadotropin releasing hormone


human chorionic gonadotropin


insulin like growth factor-1


in vitro fertilization


luteinizing hormone


müllerian inhibiting substance


messenger RNA




ribonucleic acid


transforming growth factor


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Centro de Investigaciones EndocrinológicasHospital de Niños Ricardo GutiérrezBuenos AiresArgentina

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