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Autocrine and Paracrine Regulation of the Ovary

  • Marta Tesone
  • Dalhia Abramovich
  • Griselda Irusta
  • Fernanda Parborell
Chapter

Ovarian follicular development and regression is a continuous and cyclic process that depends on a number of endocrine, paracrine, and autocrine signals. Although many of the factors involved in follicular growth have been characterized, it remains unknown why one or more, depending on species, preovulatory follicle(s) emerge as dominant and the others regress. It is postulated that the selected dominant follicle(s) possesses a higher sensitivity to FSH due to increased expression of FSH receptors. As a result, increases in estradiol and inhibin trigger a negative feedback mechanism that prevents the other follicles from continuing their development. The ovarian theca and granulosa cells also play an important role, since they produce steroid hormones required for normal follicular growth. In addition, ovarian growth factors, cytokines, and neuropeptides participate as regulators of follicular growth and in the formation of the ovarian cell compartments as well.

Keywords

Granulosa Cell Corpus Luteum Antral Follicle Follicular Development GnRH Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

21.6Glossary of Terms and Acronyms

AMH:

anti-Müllerian hormone

ANGPT1:

angiopoietin 1

ANGPT2:

angiopoietin 2

ANGPT3:

angiopoietin 3

ANGPT4:

angiopoietin 4

bFGF:

basic fibroblastic growth factor

BMP:

bone morphogenetic protein

EGF:

epidermal growth factor

FGF:

fibroblastic growth factor

FSH:

follicle-stimulating hormone

GABA:

γ-aminobutyric acid

GDF:

growth and differentiation factors

GDNF:

neurotrophic factors derived from glial cells

GnRH:

gonadotroping releasing hormone

GnRH-a:

gonadotroping releasing hormone agonist

hCG:

human Chorionic Gonadotropin

IGFBPs:

insulin like growth factor binding protein

IGF-I:

insulin like growth factor-I

IGF-II:

insulin like growth factor-II

LH:

luteinizing hormone

NGF:

nerve growth factor

NT-4/5:

neurotrophin 4/5

StAR:

steroidogenic acute regulatory protein

TGF-α:

transforming growth factor alpha

TGF:

transforming growth factor

Tie1:

angiopoietin receptor type 1

Tie2:

angiopoietin receptor type 2

Trap:

VEGF antagonist

VEGFA or VEGF:

vascular endothelial growth factor

VEGFR1 or Flt-1:

vascular endothelial growth factor receptor type 1

VEGFR2 or Flk-1/KDR:

vascular endothelial growth factor receptor type 2

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Marta Tesone
    • 1
  • Dalhia Abramovich
    • 1
  • Griselda Irusta
    • 1
  • Fernanda Parborell
    • 1
  1. 1.Institute of Experimental Biology and Medicine-CONICETBuenos AiresArgentina

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