Leptin as a Reproductive Hormone

  • Michael C. Henson
  • V. Daniel Castracane

Leptin is an adipokine (i.e., adipocytokine). Adipokines are adipocyte-derived secretory proteins that are linked to physiological mechanisms that influence energy metabolism, inflammation, and an array of pathological conditions that range from infectious disease to diabetes and from preeclampsia to cancer. After only a few years of research on these versatile physiological mediators, their obvious importance served to elevate adipose tissue from its previously accepted role as a simple storage compartment for lipids to that of a powerful endocrine organ [1, 2]. Adipokines, therefore, are now recognized as molecular agents of communication connecting adipose tissue, brain, vasculature, liver, pancreas, muscle, the immune system, and many of the specialized reproductive tissues and organs in both males and females [3].


Luteinizing Hormone Pubertal Development GnRH Release Late Follicular Phase Luteinizing Hormone Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Glossary of Terms and Acronyms


agouti-related protein


androgen receptor


androgen receptor knockout mouse


anteroventral periventricular


body mass index


amino acid sequence [V/L]E[V/L]L present in the single chain cytokine receptors required in some cases for full activation of Jak2


cocaine- and amphetamine-regulated transcript


corticotropin-releasing hormone




estradiol benzoate


estrogen receptor


extracellular-signal-regulated kinase (ERK) pathways


Gonadotripin-releasing hormone


G-protein-coupled receptor-54


human chorionic gonadotropin




intrauterine growth restriction


Janus tyrosine kinases/signal transduction and activators of transcription


cognate ligands of the GPR54


human/primate leptin


rodent leptin


obese, genetically leptin deficient, mouse


long isoform, primate leptin receptor


short isoform, primate leptin receptor


leptin receptor


a short LR isoform


long LR isoform


mitogen-activated protein kinase


melanin-concentrating hormone


neuropeptide Y


original name for Lep gene (obese)




cytochrome P450 side chain cleavage




steroidogenic factor-1


Src homology 2


soluble leptin receptor


sterodogenic acute regulatory protein


tumor necrosis factor-α


thyrotropin-releasing hormone


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyTexas TechUniversity Health Sciences CentersUSA

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