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Leptin as a Reproductive Hormone

  • Michael C. Henson
  • V. Daniel Castracane
Chapter

Leptin is an adipokine (i.e., adipocytokine). Adipokines are adipocyte-derived secretory proteins that are linked to physiological mechanisms that influence energy metabolism, inflammation, and an array of pathological conditions that range from infectious disease to diabetes and from preeclampsia to cancer. After only a few years of research on these versatile physiological mediators, their obvious importance served to elevate adipose tissue from its previously accepted role as a simple storage compartment for lipids to that of a powerful endocrine organ [1, 2]. Adipokines, therefore, are now recognized as molecular agents of communication connecting adipose tissue, brain, vasculature, liver, pancreas, muscle, the immune system, and many of the specialized reproductive tissues and organs in both males and females [3].

Keywords

Luteinizing Hormone Pubertal Development GnRH Release Late Follicular Phase Luteinizing Hormone Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Glossary of Terms and Acronyms

AGRP:

agouti-related protein

AR:

androgen receptor

ARKO:

androgen receptor knockout mouse

AVPV:

anteroventral periventricular

BMI:

body mass index

BOX2:

amino acid sequence [V/L]E[V/L]L present in the single chain cytokine receptors required in some cases for full activation of Jak2

CART:

cocaine- and amphetamine-regulated transcript

CRH:

corticotropin-releasing hormone

E2:

estradiol

E2B:

estradiol benzoate

ER:

estrogen receptor

ERK:

extracellular-signal-regulated kinase (ERK) pathways

GnRH:

Gonadotripin-releasing hormone

GPR54:

G-protein-coupled receptor-54

hCG:

human chorionic gonadotropin

IL:

interleukin

IUGR:

intrauterine growth restriction

JAK/STAT:

Janus tyrosine kinases/signal transduction and activators of transcription

KiSS-1:

cognate ligands of the GPR54

LEP:

human/primate leptin

Lep:

rodent leptin

Lepob/Lepob:

obese, genetically leptin deficient, mouse

LEPRL:

long isoform, primate leptin receptor

LEPRS:

short isoform, primate leptin receptor

LR:

leptin receptor

LRa:

a short LR isoform

LRb:

long LR isoform

MAPK:

mitogen-activated protein kinase

MCH:

melanin-concentrating hormone

NPY:

neuropeptide Y

ob:

original name for Lep gene (obese)

ORX:

orexins

P450scc:

cytochrome P450 side chain cleavage

POMC:

proopiomelanocortin

SF-1:

steroidogenic factor-1

SH2:

Src homology 2

solLR:

soluble leptin receptor

StAR:

sterodogenic acute regulatory protein

TNF-α:

tumor necrosis factor-α

TRH:

thyrotropin-releasing hormone

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyTexas TechUniversity Health Sciences CentersUSA

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