Androgens—Molecular Basis and Related Disorders

  • Christine Meaden
  • Pedro J. Chedrese

The term androgen refers to any natural or synthetic compounds that stimulate or control development and maintenance of masculine characteristics. Most commonly, androgens refer to endogenous steroid sex hormones responsible for virilizing the accessory male sex organs and secondary sex characteristics. Androgens are mainly synthesized by the testes, although females also produce small amounts, which are important for positive protein balance, maintaining strong muscles and bones, and contribute to libido. There are two major androgens secreted by the testes: testosterone and 5α-dihydrotestosterone (5α–DHT). Two weaker androgens primarily synthesized in the adrenal cortex and in smaller amounts by the testes and ovaries are dehydroepiandrosterone (DHEA) and androstenedione, which are converted metabolically to testosterone and other androgens. There is one common androgen receptor (AR) that all androgens bind to, although their target genomic responses are distinctly different. Testosterone is the most abundant androgen with 4–10 mg secreted daily in adult men. 5α-DHT binds the AR with higher affinity than all other androgens, making 5α-DHT the most potent androgen. This chapter focuses on the fundamental molecular mechanisms of the effects of androgens, androgen metabolism in males and defects in the AR that is meant to communicate the complexity of intersex disorders.


Androgen Receptor External Genitalia Androgen Receptor Gene Urogenital Sinus Androgen Insensitivity Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


18.8Glossary of Terms and Acronyms


17β-hydroxsteroid dehydrogenase


3β-hydroxysteroid dehydrogenase/Δ4-Δ5 isomerase




androgen-binding protein, a glycosylated dimeric protein secreted by the Sertoli cells homologous to steroid hormone-binding globulin

AF-1, -2 and -5:

activation function-1, -2 and -5.


androgen insensitivity syndrome


amyotrophic lateral sclerosis


absence of menstruation


anti-Müllerian hormone


androgen receptor

AR-A and AR-B:

androgen receptor isoforms


AR associated proteins


androgen response element


androgen sensitivity index


describe any bulb-shaped organ of the body


complete androgen insensitivity syndrome


computed topography


DNA-binding domain








follicle stimulating hormone


abnormal overdevelopment of the male breasts


heat shock protein


failure of the distal urethra to develop normally, resulting in a ventral urinary meatus


international units


ligand-binding domain


low density lipoproteins


luteinizing hormone


mild AIS


Müllerian-inhibiting substance


the presence of two populations of cells with different genotypes in one individual originated from a single fertilized egg


magnetic resonance imaging


cytochrome P450 aromatase


cytochrome P450 side chain cleavage


partial AIS


X-linked spinal and bulbar muscular atrophy or Kennedy Disease


steroid hormone-binding globulin, a glycosylated dimeric protein homologous to the androgen-binding protein secreted by the Sertoli cells of the testes


5α-reductase-1 gene


5α-reductase-2 gene


sex determining region of the Y chromosome


steroidogenic acute regulatory protein


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of BiologyUniversity of Saskatchewan College of Art and SciencesSaskatoonCanada

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