Regulation of the Early Steps in Gonadal Steroidogenesis

  • Steven R. King
  • Holly A. LaVoie

De novo synthesis of sex steroid hormones occurs primarily in the Leydig cells of the testes and the theca cells and theca- and granulosa-derived luteal cells of the ovary. Other major sites of de novo steroid biosynthesis include the placenta, the adrenal cortex, and the brain. In steroidogenic cells, cholesterol is taken up in response to trophic stimuli and transported into the mitochondria through the action of the steroidogenic acute regulatory protein (StAR).


Granulosa Cell Leydig Cell Sterol Regulatory Element Binding Protein StAR Gene HSD3B Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


16.5Glossary of Terms and Acronyms


3β-hydroxysteroid dehydrogenase/Δ4–Δ5 isomerase


A-kinase anchor protein


Activator Protein 1


transcription factor CCAAT/Enhancer Binding Protein


transcription factor product of the cellular protooncogene homologue of v-FOS identified as the transforming gene of the Finkel-Biskis-Jinkins murine osteosarcoma virus; member of the AP-1 family


chromatin immunoprecipitation


transcription factor product of the cellular protooncogene homologue of v-Jun identified as the transforming gene of avian sarcoma virus 17; member of the AP-1 family of transcription factors


consensus cAMP response element


transcription factor cyclic AMP response element binding protein


CRE modulator


cAMP response sequences


gene coding for P450scc


dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1




epidermal growth factor


flavin adenine dinucleotide


reduced FAD


transcription factor Forkhead box protein L2


transcription factor Fos-related antigen

GATA4 and GATA6:

members of a family of transcription factors that contain a two-zinc-finger motif and bind to the DNA sequence (A/T)GATA(A/G)


human chorionic gonadotropin


high density lipoprotein

HMG-CoA reductase:

3-hydroxy-3-methyl-glutaryl-CoA reductase


gene(s) coding for 3β-HSD


insulin-like growth factor 1


transcription factor related to c-Jun


transcription factor related to c-Jun


low density lipoprotein

Lipoid CAH:

congenital Lipoid Adrenal Hyperplasia


transcription factor Liver Receptor Homologue-1


stable cell line originated from a Leydig cell tumor


StAR homologue


murine Leydig tumor cells


nicotinamide adenine dinucleotide phosphate


reduced NADP


transcription factor nuclear receptor 4A subgroup


transcription factor SF-1


SF-1 family member LRH-1

Nur77, Nurr1 and Nor1:

family members of NR4A


cytochrome P450 17α-hydroxylase/17,20-lyase


cytochrome P450 cholesterol side-chain cleavage enzyme


peripheral benzodiazepine receptor


protein kinase A


PKA regulatory subunit


SF-1 binding element


SF-1 binding element


transcription factor steroidogenic factor 1, also termed NR5A1


transcription factor stimulatory protein 1


scavenger type receptor, class B, type 1


putative sterol response element


transcription factor sterol regulatory element binding protein


steroidogenic acute regulatory protein


START domain-containing protein 1 (StAR)


StAR-related lipid transfer domain


signal transducers and activators of transcription


voltage-dependent anion channel


transcription factor Yin Yang 1


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Scott Department of Urology Baylor College of Medicine HoustonUSA
  2. 2.Deptartment of Cell Biology and Anatomy, University of South Carolina School of MedicineColumbiaUSA

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