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The FSH Receptor: One Receptor with Multiple Forms or a Family of Receptors

  • Tim G. Rozell
  • Yonghai Li
  • Lisa C. Freeman
Chapter

The follicle stimulating hormone (FSH) receptor (FSHR) is expressed within reproductive tissues and primarily allows for control of reproductive activity in response to secretion of FSH from the pituitary gland. Specific reproductive tissues within both males and females express the FSHR, and thus FSH has important roles in the reproductive process in both genders. This chapter will describe the location and expression of the FSHR gene within the gonads, post-transcriptional and post-translational modifications of FSHR protein, mechanisms of FSH binding and activation of the FSHR, and signaling events that occur within cells following FSH binding.

Keywords

Granulosa Cell Follicle Stimulate Hormone Sertoli Cell Extracellular Domain Hormone Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Glossary of Terms and Acronyms

cAmp:

cyclic adenosine monophosphate

cDNA:

complementary deoxyribonucleic acid

ERK:

extracellular-regulated kinase

FSH:

follicle stimulating hormone

FSHR:

follicle stimulating hormone receptor

hCG:

human chorionic gonadotropin

LH:

luteinizing hormone

LHR:

luteinizing hormone receptor

LRR:

leucine-rich repeat

MAPK:

mitogen-activated protein kinase

PKA:

protein kinase A

SF-1:

steroidogenic factor-1

SFK:

Src-family kinases

TSH:

thyroid stimulating hormone

TSHR:

thyroid stimulating hormone receptor

USF-1/2:

upstream regulatory factor-1/2

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Animal Sciences & IndustryKansas State UniversityManhattanUSA
  2. 2.Department of Anatomy & PhysiologyKansas State University College of Veterinary MedicineManhattanUSA

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