Introduction to Gene Therapy


Gene therapy is broadly defined as the delivery or transferof genetic material to target cells for therapeutic purposes. Elucidation of the molecular bases of inherited diseases as well as acquired diseases, such as cancer, allows for the possibility of therapeutic interventions at the molecular level. The therapeutic benefits may be achieved by, interfering with gene function, restoring lost function, or initiating a new function in the target cells. Current methods of gene transfer include the use of viral and non-viral vectors [1–5]. Viral vectors accomplish gene transfer directly by viral-mediated infection.


Gene Therapy Adenoviral Vector Uterine Fibroid Bystander Effect Therapeutic Gene 


Glossary of Terms and Acronyms


adeno-associated viruses


type of adenovirus


adenoviral vector that expresses a dominant negative ER mutant


adenovirus expressing the marker gene β-lactamase


aldehyde dehydrogenase class 1 gene


basic fibroblast growth factor


calcium chloride


coxsackie-adenovirus receptor


cytosine deaminase plus 5-fluorocytosine




conditionally replicative adenoviruses


deoxyribonucleic acid


cell line derived from Eker rat leiomyoma


estrogen receptor


estrogen receptor element


estrogen receptor mutant




herpes simplex virus


herpes simplex virus-thymidine kinase


human leiomyoma cell line


multidrug resistance gene


multiplicity of infection


platelet-derived endothelial growth factor


ribonucleic acid


small interfering RNA


thymidine kinase – ganciclovir


tumor necroses factor


TNF apoptosis-inducing ligand


vascular endothelial growth factor


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyMeharry Medical College Center for Women Health ResearchNashvilleUSA
  2. 2.Department of Obstetrics & GynecologyUniversity of Texas Medical BranchGalvestonUSA

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