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Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells

  • Adam D. Bachstetter
  • Carmellina Gemma
  • Paula C. Bickford
Chapter

Abstract

Throughout the entire life span, stem cells are present in many organs of our body and continue to produce new cells which are critical to maintain homeostasis and to repair damaged tissues. In the brain, stem cells generate new neurons through a process called neurogenesis. With age, stem cells lose their ability to generate new cells, although the number of stem cells remains constant over time. This may be due in part to cellular stresses such as inflammation, oxidative stress, and loss of trophic factors that accumulate with age. A better understanding of the regulatory factors which control neurogenesis is necessary in order to utilize the potential of the endogenous adult stem cells to treat the degenerative condition.

Keywords

Synaptic Plasticity Satellite Cell Granule Cell Layer Contextual Fear Conditioning Peripheral Immune Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AD

Alzheimer's disease

CNS

central nervous system

GCL

granule cell layer

IL

interleukin

NSAID

nonsteroidal anti-inflammatory drug

NSCs

neural stem/progenitor cells; 6-OHDA, 6-hydroxydopamine; PD, Parkinson's disease

SGZ

subgranular zone

TNF

tumor necrosis factor-α

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Adam D. Bachstetter
    • 1
  • Carmellina Gemma
    • 1
  • Paula C. Bickford
    • 1
  1. 1.Center of Excellence for Aging and Brain Repair, College of MedicineUniversity of South FloridaTampa

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