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Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells

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Current Hypotheses and Research Milestones in Alzheimer's Disease

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Abstract

Throughout the entire life span, stem cells are present in many organs of our body and continue to produce new cells which are critical to maintain homeostasis and to repair damaged tissues. In the brain, stem cells generate new neurons through a process called neurogenesis. With age, stem cells lose their ability to generate new cells, although the number of stem cells remains constant over time. This may be due in part to cellular stresses such as inflammation, oxidative stress, and loss of trophic factors that accumulate with age. A better understanding of the regulatory factors which control neurogenesis is necessary in order to utilize the potential of the endogenous adult stem cells to treat the degenerative condition.

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Abbreviations

AD:

Alzheimer's disease

CNS:

central nervous system

GCL:

granule cell layer

IL:

interleukin

NSAID:

nonsteroidal anti-inflammatory drug

NSCs:

neural stem/progenitor cells; 6-OHDA, 6-hydroxydopamine; PD, Parkinson's disease

SGZ:

subgranular zone

TNF:

tumor necrosis factor-α

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Authors and Affiliations

  1. Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, FL

    Adam D. Bachstetter, Carmellina Gemma & Paula C. Bickford

Authors
  1. Adam D. Bachstetter
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  2. Carmellina Gemma
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  3. Paula C. Bickford
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Corresponding author

Correspondence to Paula C. Bickford .

Editor information

Editors and Affiliations

  1. Mind/Brain Program of the International Center of Biomedicine, University of Chile, Santiago, Chile

    Ricardo B. Maccioni

  2. School of Medicine Miami, University of Miami, Florida, USA

    Ricardo B. Maccioni

  3. College of Sciences, University of Texas at San Antonio, San Antonio, Texas, 78249-0661, USA

    George Perry

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Bachstetter, A.D., Gemma, C., Bickford, P.C. (2009). Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells. In: Maccioni, R.B., Perry, G. (eds) Current Hypotheses and Research Milestones in Alzheimer's Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-87995-6_3

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