Follicular Neoplasm, Hürthle Cell Type/Suspicious for a Follicular Neoplasm, Hürthle Cell Type

  • William C. Faquin
  • Claire W. Michael
  • Andrew A. Renshaw
  • Philippe Vielh


Ewing coined the term “Hürthle cell” in 1928 based upon the description of a cell made by Hürthle in 1894. The term has become entrenched in the thyroid lexicon, even though Hürthle’s original description is now believed to represent a parafollicular or C-cell of the thyroid gland.1 In 1898, Askanazy was the first to describe the follicular-derived Hürthle cell as we know it today.2 The Hürthle cell (also called Askanazy cell, oxyphilic cell, and oncocyte) is defined morphologically as a thyroid follicular cell with an abundance of finely granular cytoplasm. Most Hürthle cells have an enlarged, round to oval nucleus, and some have a prominent nucleolus.


Papillary Thyroid Carcinoma Papillary Carcinoma Follicular Cell Cell Adenoma Medullary Carcinoma 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • William C. Faquin
    • 1
  • Claire W. Michael
    • 2
  • Andrew A. Renshaw
    • 3
  • Philippe Vielh
    • 4
  1. 1.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of PathologyUniversity of Michigan Medical CenterAnn ArborUSA
  3. 3.Department of PathologyBaptist Hospital of MiamiMiamiUSA
  4. 4.Department of PathologyInstitute de Cancerologie Gustave RoussyVillejuifFrance

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