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Follicular Neoplasm, Hürthle Cell Type/Suspicious for a Follicular Neoplasm, Hürthle Cell Type

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Book cover The Bethesda System for Reporting Thyroid Cytopathology

Abstract

Ewing coined the term “Hürthle cell” in 1928 based upon the description of a cell made by Hürthle in 1894. The term has become entrenched in the thyroid lexicon, even though Hürthle’s original description is now believed to represent a parafollicular or C-cell of the thyroid gland.1 In 1898, Askanazy was the first to describe the follicular-derived Hürthle cell as we know it today.2 The Hürthle cell (also called Askanazy cell, oxyphilic cell, and oncocyte) is defined morphologically as a thyroid follicular cell with an abundance of finely granular cytoplasm. Most Hürthle cells have an enlarged, round to oval nucleus, and some have a prominent nucleolus.

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Author information

Authors and Affiliations

  1. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    William C. Faquin M.D., Ph.D.

  2. Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA

    Claire W. Michael M.D.

  3. Department of Pathology, Baptist Hospital of Miami, Miami, FL, USA

    Andrew A. Renshaw M.D.

  4. Department of Pathology, Institute de Cancerologie Gustave Roussy, Villejuif, France

    Philippe Vielh M.D., Ph.D.

Authors
  1. William C. Faquin M.D., Ph.D.
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  2. Claire W. Michael M.D.
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  3. Andrew A. Renshaw M.D.
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  4. Philippe Vielh M.D., Ph.D.
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Editor information

Editors and Affiliations

  1. N. Wolfe Street, PATH 406 600, Baltimore, 21287, U.S.A.

    Syed Z. Ali

  2. Brigham & Women's Hospital, Harvard Medical School, Francis St. 75, Boston, 02115, U.S.A.

    Edmund S. Cibas

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Faquin, W.C., Michael, C.W., Renshaw, A.A., Vielh, P. (2010). Follicular Neoplasm, Hürthle Cell Type/Suspicious for a Follicular Neoplasm, Hürthle Cell Type. In: Ali, S., Cibas, E. (eds) The Bethesda System for Reporting Thyroid Cytopathology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-87666-5_6

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  • DOI: https://doi.org/10.1007/978-0-387-87666-5_6

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-87665-8

  • Online ISBN: 978-0-387-87666-5

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