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Pain Management in Elderly Patients

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Essentials of Pain Management

Abstract

The aging process leads to progressive physiological changes. Individuals are more vulnerable to injury at both extremes of age and are more adaptable when bodily injury occurs in adulthood. This chapter will emphasize the changes that one experiences with age. Chronological age refers to age according to birth date, whereas biological age is the estimated age based on the degree of physiological degeneration or loss of physiologic reserve (Lee 2003). Physiologic changes do not necessarily parallel that of chronological age. Furthermore, specific physiological processes may age at different rates in the same individual. In addition to normal physiologic changes that occur with aging, coexisting medical conditions are also more prevalent in the elderly. The normal physiological changes associated with aging are distinct from changes brought on by disease. The pharmacokinetic, pharmacodynamic, neurologic, and cognitive changes in the elderly are affected as much by normal physiology as they are by disease.

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References

  • Barker JD, Jr, de Carle DJ, Anuras S. Chronic excessive acetaminophen use and liver damage. Ann Intern Med. 1977;87:299–301.

    PubMed  Google Scholar 

  • Berger JM. Pain management. In: Silverstein JH, Rooke GA, Reves JG, editors. Geriatric anesthesiology. 2nd ed. New York, NY: Springer; 2007. pp. 308–21.

    Google Scholar 

  • Bernabei R, Gambassi G, Lapane K, Landi F, Gatsonis C, Dunlop R, Lipsitz L, Steel K, Mor V. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. JAMA 1998;279:1877–82.

    Article  PubMed  CAS  Google Scholar 

  • Berry SD, Miller RR. Falls: epidemiology, pathophysiology, and relationship to fracture. Curr Osteoporos Rep. 2008;6:149–54.

    Article  PubMed  Google Scholar 

  • Boswell MV, Trescot AM, Datta S, Schultz DM, Hansen HC, Abdi S, Sehgal N, Shah RV, Singh V, Benyamin RM, Patel VB, Buenaventura RM, Colson JD, Cordner HJ, Epter RS, Jasper JF, Dunbar EE, Atluri SL, Bowman RC, Deer TR, Swicegood JR, Staats PS, Smith HS, Burton AW, Kloth DS, Giordano J, Manchikanti L. Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain. Pain Phys. 2007;10:7–111.

    Google Scholar 

  • Clark RF, Wei EM, Anderson PO. Meperidine: therapeutic use and toxicity. J Emerg Med. 1995;13:797–802.

    Article  PubMed  CAS  Google Scholar 

  • Danziger LH, Martin SJ, Blum RA. Central nervous system toxicity associated with meperidine use in hepatic disease. Pharmacotherapy 1994;14:235–8.

    PubMed  CAS  Google Scholar 

  • Ferrell BA, Ferrell BR, Rivera L. Pain in cognitively impaired nursing home patients. J Pain Symptom Manage. 1995;10:591–8.

    Article  PubMed  CAS  Google Scholar 

  • Fineberg IC, Wenger NS, Brown-Saltzman K. Unrestricted opiate administration for pain and suffering at the end of life: knowledge and attitudes as barriers to care. J Palliat Med. 2006;9:873–83.

    Article  PubMed  Google Scholar 

  • Gibson RE, Harden M, Byles J, Ward J. Incidence of falls and fall-related outcomes among people in aged-care facilities in the Lower Hunter region, NSW. N S W Public Health Bull. 2008;19:166–9.

    Article  PubMed  Google Scholar 

  • Gibson SJ, Helme RD. Age-related differences in pain perception and report. Clin Geriatr Med. 2001;17:433–56, v–vi.

    Article  PubMed  CAS  Google Scholar 

  • Haragsim L, Dalal R, Bagga H, Bastani B. Ketorolac-induced acute renal failure and hyperkalemia: report of three cases. Am J Kidney Dis. 1994;24:578–80.

    PubMed  CAS  Google Scholar 

  • Hurley AC, Volicer L. Evaluation of pain in cognitively impaired individuals. J Am Geriatr Soc. 2001;49:1397–8.

    Article  PubMed  CAS  Google Scholar 

  • Jano E, Aparasu RR. Healthcare outcomes associated with beers’ criteria: a systematic review. Ann Pharmacother. 2007;41:438–47.

    Article  PubMed  Google Scholar 

  • Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS. Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 2003;23:802–5.

    Article  PubMed  CAS  Google Scholar 

  • Labropoulos N, Gasparis AP, Pefanis D, Leon LR, Jr, Tassiopoulos AK. Secondary chronic venous disease progresses faster than primary. J Vasc Surg. 2009;49:704–10.

    Article  PubMed  Google Scholar 

  • Lane JE, Belson MG, Brown DK, Scheetz A. Chronic acetaminophen toxicity: a case report and review of the literature. J Emerg Med. 2002;23:253–6.

    Article  PubMed  Google Scholar 

  • Lee CY. Manual of anaesthesia. New York, NY: McGraw-Hill; 2006.

    Google Scholar 

  • Leung JM. Elderly patient. In: Stoelting RK, Miller RD, editors. Basics of anesthesia Philadelphia, PA: Churchill Livingstone Elsevier; 2007. pp. 518–29.

    Google Scholar 

  • Manchikanti L, Singh V, Derby R, Schultz DM, Benyamin RM, Prager JP, Hirsch JA. Reassessment of evidence synthesis of occupational medicine practice guidelines for interventional pain management. Pain Phys. 2008;11:393–482.

    Google Scholar 

  • Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57:6–14.

    Article  PubMed  CAS  Google Scholar 

  • Mann C, Pouzeratte Y, Eledjam JJ. Postoperative patient-controlled analgesia in the elderly: risks and benefits of epidural versus intravenous administration. Drugs Aging 2003;20: 337–45.

    Article  PubMed  CAS  Google Scholar 

  • Mano Y, Usui T, Kamimura H. In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans. Biopharm Drug Dispos. 2006;27:267–73.

    Article  PubMed  CAS  Google Scholar 

  • McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56:163–84.

    Article  PubMed  CAS  Google Scholar 

  • Meyhoff CS, Hesselbjerg L, Koscielniak-Nielsen Z, Rasmussen LS. Biphasic cardiac output changes during onset of spinal anaesthesia in elderly patients. Eur J Anaesthesiol. 2007;24:770–5.

    Article  PubMed  CAS  Google Scholar 

  • Morgan GE, Mikhail MS, Murray MJ. Clinical anesthesiology. 4th ed. New York, NY: McGraw-Hill; 2007.

    Google Scholar 

  • Pargeon KL, Hailey BJ. Barriers to effective cancer pain management: a review of the literature. J Pain Symptom Manage. 1999;18:358–68.

    Article  PubMed  CAS  Google Scholar 

  • Pearson EC, Woosley RL. QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system. Pharmacoepidemiol Drug Saf. 2005;14:747–53.

    Article  PubMed  CAS  Google Scholar 

  • Prough DS. Anesthetic pitfalls in the elderly patient. J Am Coll Surg. 2005;200:784–94.

    Article  PubMed  Google Scholar 

  • Sadean MR, Glass PS. Pharmacokinetics in the elderly. Best Pract Res Clin Anaesthesiol. 2003;17:191–205.

    Article  PubMed  CAS  Google Scholar 

  • Schoch PH, Ranno A, North DS. Acute renal failure in an elderly woman following intramuscular ketorolac administration. Ann Pharmacother 1992;26:1233–6.

    PubMed  CAS  Google Scholar 

  • Schulman S, Henriksson K. Interaction of ibuprofen and warfarin on primary haemostasis. Br J Rheumatol. 1989;28:46–9.

    Article  PubMed  CAS  Google Scholar 

  • Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther. 1987;240:159–66.

    PubMed  CAS  Google Scholar 

  • Sticherling C, Schaer BA, Ammann P, Maeder M, Osswald S. Methadone-induced Torsade de pointes tachycardias. Swiss Med Wkly. 2005;135:282–5.

    PubMed  CAS  Google Scholar 

  • Stoelting RK, Miller R. Basics of anesthesia. 5th ed. Philadelphia, PA: Churchill Livingston; 2007.

    Google Scholar 

  • Stone J, Smyth R, Carson A, Lewis S, Prescott R, Warlow C, Sharpe M. Systematic review of misdiagnosis of conversion symptoms and “hysteria”. BMJ 2005;331:989.

    Article  PubMed  Google Scholar 

  • Szeto HH, Inturrisi CE, Houde R, Saal S, Cheigh J, Reidenberg MM. Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. Ann Intern Med. 1977;86:738–41.

    PubMed  CAS  Google Scholar 

  • van Dijk KN, Plat AW, van Dijk AA, Piersma-Wichers M, de Vries-Bots AM, Slomp J, de Jong-van den Berg LT, Brouwers JR. Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype. Thromb Haemost. 2004;91:95–101.

    PubMed  Google Scholar 

  • Verbeeck RK. Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs. Clin Pharmacokinet 1990;19:44–66.

    Article  PubMed  CAS  Google Scholar 

  • Visser LE, van Schaik RH, van Vliet M, Trienekens PH, De Smet PA, Vulto AG, Hofman A, van Duijn CM, Stricker BH. Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants. Clin Pharmacol Ther. 2005;77:479–85.

    Article  PubMed  CAS  Google Scholar 

  • Vuyk J. Pharmacodynamics in the elderly. Best Pract Res Clin Anaesthesiol. 2003;17:207–18.

    Article  PubMed  CAS  Google Scholar 

  • Yablon SA, Rock WA, Jr, Nick TG, Sherer M, McGrath CM, Goodson KH. Deep vein thrombosis: prevalence and risk factors in rehabilitation admissions with brain injury. Neurology 2004;63:485–91.

    PubMed  CAS  Google Scholar 

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Akhtar, S., Rappa, R., Ghori, M.K. (2011). Pain Management in Elderly Patients. In: Vadivelu, N., Urman, R., Hines, R. (eds) Essentials of Pain Management. Springer, New York, NY. https://doi.org/10.1007/978-0-387-87579-8_32

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  • DOI: https://doi.org/10.1007/978-0-387-87579-8_32

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