Anatomic and Physiologic Principles of Pain

  • Xing Fu
  • Dan Froicu
  • Raymond Sinatra


Pain is the most frequent cause of suffering and disability and is the most common reason that people seek medical attention. It is a major symptom in many medical conditions, significantly interfering with a person’s quality of life and general functioning. To understand the physiology and the mechanism of pain as well as optimal methods of control, one must appreciate the anatomical pathways that transmit nociceptive information to the brain. For a better comprehension of the anatomical pathways we divided it into four parts: the peripheral system, the spinal and medullary dorsal horn system, and the ascending and supraspinal system.


Dorsal Horn Primary Afferent Neuron Visceral Pain Somatic Pain Spinothalamic Tract 
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  1. Besson JM. Theneuro biology of pain. Lancet. 1999 May 8;353(9164):1610–5.PubMedCrossRefGoogle Scholar
  2. Craig AD, Reiman EM, Evans A, Bushnell MC. Functional imaging of an illusion of pain. Nature. 1996 Nov 21;384(6606):258–60.PubMedCrossRefGoogle Scholar
  3. Davis KD, Taylor SJ, Crawley AP, Wood ML, Mikulis DJ. Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol. 1997 Jun;77(6):3370–80.PubMedGoogle Scholar
  4. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science. 1997 Aug 15;277(5328):968–71.PubMedCrossRefGoogle Scholar
  5. Rygh LJ, Svendsen F, Fiska A, Haugan F, Hole K, Tjolsen A. Long-term potentiation in spinal nociceptive systems – how acute pain may become chronic. Psychoneuroendocrinology. 2005 Nov;30(10):959–64.Google Scholar
  6. Vanegas H, Schaible HG. Descending control of persistent pain: inhibitory or facilitatory? Brain Res Rev. 2004 Nov;46(3):295–309.PubMedCrossRefGoogle Scholar
  7. Zeilhofer HU. Synaptic modulation in pain pathways. Rev Physiol Biochem Pharmacol. 2005;154:73–100.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Xing Fu
    • 1
  • Dan Froicu
    • 1
  • Raymond Sinatra
    • 2
  1. 1.Department of AnesthesiologyYale University School of MedicineNew HavenUSA
  2. 2.Yale University School of MedicineNew HavenUSA

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