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Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O2 Sensing

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Textbook of Pulmonary Vascular Disease

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Abstract

Mammals possess a homeostatic O2-sensing system that comprises the resistance pulmonary arteries, ductus arteriosus, carotid body, neuroepithelial body, systemic arteries, fetal adrenomedullary cell, and fetoplacental arteries. Together these specialized tissues form a homeostatic system that increases the organism’s ability to survive hypoxia, whether encountered during development, at altitude, or during disease. Thus, the homeostatic O2-sensing system optimizes O2 uptake and delivery. One important part of the homeostatic O2-sensing system is hypoxic pulmonary vasoconstriction (HPV), a vasomotor response of resistance pulmonary arteries to alveolar hypoxia, that optimizes ventilation/perfusion matching and optimizes systemic O2 tension. The core mechanisms of hypoxic pulmonary vasoconstriction resides in the smooth muscle cell, although it is modulated by the endothelium. This chapter explores and updates the redox theory for the mechanism of hypoxic pulmonary vasoconstriction.

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  1. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA

    Stephen L. Archer

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  1. Stephen L. Archer
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  2. John J. Ryan
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Correspondence to Stephen L. Archer .

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Editors and Affiliations

  1. Departments of Medicine, COMRB Rm. 3131 (MC 719), University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, 60612, Illinois, USA

    Jason X. -J. Yuan

  2. 310 Admin.Office Building (MC 672), University of Illinois at Chicago, 1737 W. Polk Street, Suite 310, Chicago, 60612, Illinois, USA

    Joe G.N. Garcia

  3. Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0623, California, USA

    John B. West

  4. Dept. Pulmonary & Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, 02114, Massachusetts, USA

    Charles A. Hales

  5. Department of Medicine, University of Chicago Medical Center, 5841 S. Maryland Ave., Chicago, 60637, Illinois, USA

    Stuart Rich

  6. Department of Medicine, University of Chicago School of Medicine, 5841 S. Maryland Ave., Chicago, 60637, Illinois, USA

    Stephen L. Archer

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Archer, S.L., Ryan, J.J. (2011). Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O2 Sensing. In: Yuan, JJ., Garcia, J., West, J., Hales, C., Rich, S., Archer, S. (eds) Textbook of Pulmonary Vascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-87429-6_19

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