Abstract
We applied a theoretical model of muscle tissue O2 transport to investigate the effects of flow redistribution on rat soleus muscle oxygenation. The situation chosen was the anaerobic threshold where redistribution of flow is expected to have the largest impact. In the basic situation all capillaries received an equal proportion of the total flow through the tissue, resulting in 4.7% anoxic tissue and a mean tissue PO2 = 3.62 kPa. Both a redistribution of flow where 1) capillaries in blocks of tissue receiving 50% of the basic flow alternated with tissue blocks with capillaries receiving 150% of the basic flow (6.8% anoxic tissue; mean tissue PO2 = 3.32 kPa) and 2) matching flow to O2 consumption (3.3% anoxic tissue; mean tissue PO2 = 3.60 kPa) had little effect. When overall flow was decreased by 20%, the anoxic tissue increased to 7.6% and the mean tissue PO2 decreased to 3.22 kPa. The conclusion from these model calculations is, that flow redistribution has little impact on skeletal muscle oxygenation, which is in line with earlier findings for rat heart.
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References
L. Hoofd and Z. Turek, in: Adv. Exper. Med. Biol., Vol. 345, edited by P. Vaupel, R. Zander, and D.F. Bruley (Plenum Press, New York and London, 1994), pp. 275–282.
Z. Turek, L. Hoofd, S. Batra, and K. Rakusan, The effect of realistic geometry of capillary networks on tissue Po2 in hypertrophied rat heart. in: Adv. Exper. Med. Biol., Vol. 317,edited by W. Erdmann and D.F. Bruley (Plenum Press, New York and London, 1992) pp. 567–572.
H. Degens, D. Deveci, A. Botto-van Bemden, L.J.C. Hoofd, and S. Egginton, Maintenance of heterogeneity of capillary spacing is essential for adequate oxygenation in the soleus muscle of the growing rat. Microcirc. 13,467–476 (2006)
L. Hoofd, Calculation of oxygen pressures in tissue with anisotropic capillary orientation. I: Twodimensional analytical solution for arbitrary capillary characteristics. Math. Biosci. 129, 1–23 (1995)
L. Hoofd, Updating the Krogh model - assumptions and extensions. in: Oxygen Transport in Biological Systems, Soc. Exper. Biol. Seminar Series 51,edited by S. Egginton and H.F. Ross (Cambridge University Press, Cambridge, 1992) pp. 197–229.
C. Bos, L. Hoofd, and T. Oostendorp, The effect of separate red blood cells on capillary tissue oxygenation calculated with a numerical model. IMA J. Math. Appl. Med. Biol. 13, 259–274 (1996)
L. Hoofd and C. Bos, Extraction pressures calculated for rat heart and dog skeletal muscle and application in models of tissue oxygenation. in: Adv. Exper. Med. Biol., Vol. 428, edited by D.K. Harrison and D.T. Delpy (Plenum Press, New York, 1998) pp. 679–685.
C.G. Bos, Mathematical modelling of oxygen transport from capillaries to tissue,(Dissertation Thesis, University of Nijmegen, the Netherlands, 1997) pp. 78-83
D. Goldman and A.S. Popel, A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport, J. Theor. Biol. 206, 181–194 (2000)
L. Hoofd, Calculation of oxygen pressures in tissue with anisotropic capillary orientation. II: Coupling of two-dimensional planes. Math. Biosci. 129,25–39 (1995)
B.J. van Beek-Harmsen, M.A. Bekedam, H.M. Feenstra, F.C. Visser, and W.J. van der Laarse, Determination of myoglobin concentration and oxidative capacity in cryostat sections of human and rat skeletal muscle fibres and rat cardiomyocytes. Hist. Cell Biol. 121, 335-342 (2004).
A. Krogh, The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J. Physiol. 52, 409–415 (1919)
W.J. Federspiel, A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber. Biophys. J. 49, 857–868 (1986)
P.L. Altman, J.F. Gibson, and C.C. Wang, in: Handbook of Respiration,edited by D.S. Dittmer and R.M. Grebe (Saunders, Philadelphia & London, 1958) pp. 6–9.
L.F.M. van Zutphen, V. Baumans, and A.C. Beynen (eds.), Proefdieren en dierproeven. Bunge Scientific Publishers, Utrecht, 1991 (1st ed), pp. 1-365.
R.B. Armstrong, and M.H. Laughlin, Blood flows within and among rat muscles as a function of time during high speed treadmill exercise. J. Physiol. 344, 189-208 (1983)
Y. Kano, S. Shimegi, H. Furukawa, H. Matsudo, and T. Mizuta, Effects of aging on capillary number and luminal size in rat soleus and plantaris muscles. J. Gerontol. 57, B422-B427 (2002)
D. Goldman, R.M. Bateman, and C.G. Ellis, Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am. J. Physiol. Heart Circ. Physiol. 290, 2277–2285 (2006).
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Hoofd, L., Degens, H. (2009). The Influence Of Flow Redistribution On Working Rat Muscle Oxygenation. In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_9
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