Advertisement

Brain Oxygen Balance Under Various Experimental Pathophysiologycal Conditions

  • Michal Schechter
  • Judith Sonn
  • Avraham Mayevsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

Abstract

Normally, brain tissue copes with negative oxygen balance by increasing cerebral blood flow (CBF). We examined the effects of increasing oxygen demand, by inducing spreading depression (SD) under various oxygen balance states, on brain O2 balance. The Tissue Vitality Monitoring System was used, which enables real time simultaneous in vivomonitoring of CBF, mitochondrial NADH and tissue HbO2 from the same region of the cerebral cortex. SD was induced during normoxia, hypoxia, hyperoxia, ischemia, and in normal and ischemic brain after systemic epinephrine dministration. Under normoxia, hyperoxia and ischemia & epinephrine, the compensation of energy demand induced by SD, was carried out by increasing CBF. The higher oxygen delivery under hyperoxia and epinephrine did not change the pattern of recovery from SD as compared to normoxia, whereas in the ischemic and hypoxic brain, the recovery from SD was prolonged, indicating a lake in oxygen delivery. Epinephrine infusion in the ischemic rat, decreased oxyhemoglobin utilization during SD, indicating that tissue oxygen balance improves even under higher oxygen demand induced by SD.

Keywords

Cerebral Blood Flow Ischemic Brain Cortical Spreading Depression Spreading Depression Oxygen Balance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. Cooper, H. J. Crow, W. Greywalter, and A. L. Winter, Regional control of cerebral vascular reactivity and oxygen supply in man, Brain Res. 3, 174-179 (1966)PubMedCrossRefGoogle Scholar
  2. 2.
    T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, Cortical spreading depression causes and coincides with tissue hypoxia, Nat. Neurosci. 10, 754-762 (2007)PubMedCrossRefGoogle Scholar
  3. 3.
    J. Sonn and A. Mayevsky, Effects of brain oxygenation on metabolic, hemodynamic, ionic and electrical responses to spreading depression in the rat, Brain Res. 882, 212-216 (2000)PubMedCrossRefGoogle Scholar
  4. 4.
    A. Chieregato, A. Tanfani, C. Compagnone, R. Pascarella, L. Targa, and E. Fainardi, Cerebral blood flow in traumatic contusions is predominantly reduced after an induced acute elevation of cerebral perfusion pressure, Neurosurgery. 60, 115-2 (2007)PubMedCrossRefGoogle Scholar
  5. 5.
    H. Kutai-Asis, E. Barbiro-Michaely, A. Deutsch, and A. Mayevsky, Fiber optic based multiparametric spectroscopy in vivo: Toward a new quantitative tissue vitality index, SPIE Proc. 6083, 608310-608310- 10 (2006)CrossRefGoogle Scholar
  6. 6.
    E. Meirovithz, J. Sonn, and A. Mayevsky, Effect of hyperbaric oxygenation on brain hemodynamics, hemoglobin oxygenation and mitochondrial NADH, Brain Res. Rev. 54, 294-304 (2007)PubMedCrossRefGoogle Scholar
  7. 7.
    A. Mayevsky and G. Rogatsky, Mitochondrial function in vivoevaluated by NADH fluorescence: From animal models to human studies, Am. J. Physiol Cell Physiol. ., (2007)Google Scholar
  8. 8.
    A. J. Hansen, B. Quistorff, and A. Gjedde, Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression, Acta Physiol. Scand. 109, 1-6 (1980)PubMedCrossRefGoogle Scholar
  9. 9.
    T. Back, K. Kohno, and K. A. Hossmann, Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: Effect on blood flow, tissue oxygenation and electroencephalogram, J. CBF Metab. 14, 12-19 (1994)Google Scholar
  10. 10.
    A. Mayevsky and H. R. Weiss, Cerebral blood flow and oxygen consumption in cortical spreading depression, J. CBF Metab. 11, 829-836 (1991)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Michal Schechter
    • 1
  • Judith Sonn
    • 1
  • Avraham Mayevsky
    • 1
  1. 1.The Mina&Everard Goodman Faculty of Life Sciences and The Leslie and Susan Gonda Multidisciplinary Brain Research CenterBar-Ilan UniversityRamat-GanIsrael 52900

Personalised recommendations