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Brain Tissue Oxygen Consumption And Supply Induced By Neural Activation:

Determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex
  • Kazuto Masamoto
  • Alberto Vazquez
  • Ping Wang
  • Seong-Gi Kim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

Abstract

The dynamic changes in cerebral metabolic rate of oxygen (CMRO2) and oxygen supply during brain functions have not been well-characterized. To examine this issue, experiments with electrophysiology, oxygen microelectrode and laser-Doppler flowmetry were performed in the anesthetized rat somatosensory cortex. During neural activation, brain tissue partial pressure of oxygen (Po2) and local cerebral blood flow (CBF) were similarly increased. To separate the Po2 changes originating from the increase in CMRO2 and the increase in oxygen supply, the same experiments were repeated under a vasodilator-induced hypotension condition in which evoked CBF change was minimal. In this condition, evoked Po2 monotonically decreased, indicating an increase in CMRO2. Then, CMRO2 was determined at resting as well as activation periods using a dynamic oxygen exchange model. Our results indicated that the changes in CMRO2 were linearly related with the summation of evoked field potentials and further showed that the oxygen supply in the normal condition was about 2.5 times larger than the demand. However, this oxygen oversupply was not explainable by the change in CBF alone, but at least partly by the increase in oxygenation levels at pre-capillary arterioles (e.g., 82% to 90% O2 saturation level) when local neural activity was evoked.

Keywords

Cerebral Blood Flow Oxygen Supply Cereb Blood Flow Cerebral Metabolic Rate Blood Volume Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kazuto Masamoto
    • 1
  • Alberto Vazquez
    • 2
  • Ping Wang
    • 2
  • Seong-Gi Kim
    • 2
  1. 1.National Institute of Radiological Sciences Molecular Imaging CenterChiba 263-8555Japan
  2. 2.Department of RadiologyUniversity of PittsburghPittsburghUSA

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