Abstract
The use of Oxygen-17 MRI provides great promise for the clinically-useful quantification of metabolism. To bring techniques based on 17O closer to clinical application, we demonstrate imaging of metabolically generated H2 17O in pigs after 17O2 delivery with increased temporal resolution T1ρ-weighted imaging and precision delivery of 17O2 gas. The kinetics of the appearance of H2 17O in pig brains are displayed with one to two minutes of 17O2 delivery, the shortest delivery times reported in the literature. It is also shown that H2 17O concentrations can be quantified with single shot T1ρ imaging based on a balanced steady state free precession readout, and that with this strategy pausing to reduce T1 saturation increases sensitivity to H2 17O over acquisition in the steady state. Several additional considerations with this sequence, which can be generalized to any pre-encoding cluster, such as energy deposition are considered.
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References
D. R. Tailor, J. E. Baumgardner, R. R. Regatte, J. S. Leigh, R. Reddy, Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system, Neuroimage 22(2), 611-618 (2004).
X. H. Zhu, N. Zhang, Y. Zhang, X. Zhang, K. Ugurbil, W. Chen, In vivo 17O NMR approaches for brain study at high field, NMR Biomed 18(2), 83-103 (2005).
A. J. de Crespigny, H. E. D’Arceuil, T. Engelhorn, M. E. Moseley, MRI of focal cerebral ischemia using (17)O-labeled water, Magn Reson Med 43(6), 876-883 (2000).
I. Ronen, H. Merkle, K. Ugurbil, G. Navon, Imaging of H217O distribution in the brain of a live rat by using proton-detected 17O MRI, Proc Natl Acad Sci USA 95(22), 12934-12939 (1998).
T. Arai, S. Nakao, S. Morikawa, T. Inubushi, T. Yokoi, K. Shimizu, K. Mori, Measurement of local cerebral blood flow by magnetic resonance imaging: in vivo autoradiographic strategy using 17O-labeled water, Brain Res Bull 45(5), 451-456 (1998).
R. Reddy, A. H. Stolpen, J. S. Leigh, Detection of 17O by proton T1 rho dispersion imaging, J Magn Reson B 108(3), 276-279 (1995).
A. Borthakur, J. Hulvershorn, E. Gualtieri, A. J. Wheaton, S. Charagundla, M. A. Elliott, R. Reddy, A pulse sequence for rapid in vivo spin-locked MRI, J Magn Reson Imaging 23(4), 591-596 (2006).
K. Scheffler, S. Lehnhardt, Principles and applications of balanced SSFP techniques, Eur Radiol 13(11), 2409-2418 (2003).
A. L. Hopkins, E. M. Haacke, J. Tkach, R. G. Barr, C. B. Bratton, Improved sensitivity of proton MR to oxygen-17 as a contrast agent using fast imaging: detection in brain, Magn Reson Med 7(2), 222-229 (1988).
J. Pekar, L. Ligeti, Z. Ruttner, R. C. Lyon, T. M. Sinnwell, P. van Gelderen, D. Fiat, C. T. Moonen, A. C. McLaughlin, In vivo measurement of cerebral oxygen consumption and blood flow using 17O magnetic resonance imaging, Magn Reson Med 21(2), 313-319 (1991).
X. Zhang, X. H. Zhu, R. Tian, Y. Zhang, H. Merkle, W. Chen, Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil, Magma 16(2), 77-85 (2003).
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Mellon, E.A. et al. (2009). Single Shot T1ρ Magnetic Resonance Imaging Of Metabolically Generated Water In Vivo . In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_42
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DOI: https://doi.org/10.1007/978-0-387-85998-9_42
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