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New Measurements For Assessment Of Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy

  • Dominique De Smet
  • Joke Vanderhaegen
  • Gunnar Naulaers
  • Sabine Van Huffel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

References

Some preterm infants have poor cerebral autoregulation. The concordance between cerebral intravascular oxygenation (HbD), computed as the difference between oxygenated (HbO2) and deoxygenated (Hb) haemoglobin, and mean arterial blood pressure (MABP) reflects impaired autoregulation. As HbD is not an absolute value, we developed mathematics to prove that the cerebral tissue oxygenation (TOI), an absolute signal computed as the ratio of HbO2 to total haemoglobin (Hb+HbO2), may replace HbD. In the meantime, we attempt to theoretically predict the true level of autoregulation of a patient by defining a critical percentage of the signal recording time (CPRT). 20 preterm infants with need for intensive care were studied in the first days of life. HbD and TOI were obtained with the NIRO-300 (© Hamamatsu, Japan). Invasive MABP was measured continuously. All mathematics showed a strong similarity between HbD and TOI.

Keywords

Cerebral Blood Flow Mean Square Error Premature Infant Mean Arterial Blood Pressure Cerebral Autoregulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Dominique De Smet
    • 1
  • Joke Vanderhaegen
    • 2
  • Gunnar Naulaers
    • 2
  • Sabine Van Huffel
    • 3
  1. 1.Kasteelpark ArenbergBelgium
  2. 2.Neonatal Intensive Care UnitUniversity Hospitals GasthuisbergKULeuvenBelgium
  3. 3.SCD Dept. of Electrical EngineeringKULeuvenBelgium

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