The Relationship Between Vascular Oxygen Distribution And Tissue Oxygenation

  • Alexandru Daşu
  • Iuliana Toma-Daşu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)


Tumour oxygenation could be investigated through several methods that use various measuring principles and can therefore highlight its different aspects. The results have to be subsequently correlated, but this might not be straightforward due to intrinsic limitations of the measurement methods. This study describes an analysis of the relationship between vascular and tissue oxygenations that may help the interpretation of results. Simulations have been performed with a mathematical model that calculates the tissue oxygenation for complex vascular arrangements by taking into consideration the oxygen diffusion into the tissue and its consumption at the cells. The results showed that while vascular and tissue oxygenations are deterministically related, the relationship between them is not unequivocal and this could lead to uncertainties when attempting to correlate them. However, theoretical simulation could bridge the gap between the results obtained with various methods.


Tissue Oxygenation Theoretical Simulation Tumour Oxygenation Human Nonsmall Cell Lung Cancer Advanced Squamous Cell Carcinoma 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Alexandru Daşu
    • 1
  • Iuliana Toma-Daşu
    • 2
  1. 1.Department of Radiation PhysicsNorrland University HospitalSweden
  2. 2.Department of Medical Radiation PhysicsStockholm University and Karolinska InstitutetSweden

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