Mathematical Modeling of The Interaction Between Oxygen, Nitric Oxide And Superoxide

  • Donald G. Buerk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)


Computer simulations were performed based on a multiple chemical species convection-diffusion model with coupled biochemical reactions for oxygen (O2), nitric oxide (NO), superoxide (O2·-), peroxynitrite (ONOO-), nitrite (NO2 -) and nitrate (NO3 -) in cylindrical geometry with blood flow through a 30 ⎧m diameter arteriole. Steady state concentration gradients of all chemical species were predicted for different O2·- production rates, superoxide dismutase (SOD) concentrations, and blood flow rates. Effects of additional O2·- production from dysfunctional endothelial nitric oxide synthase (eNOS) were also simulated. The model predicts that convection is essential for characterizing O2 partial pressure gradients (PO2) in the bloodstream and surrounding tissue, but has little direct effect on NO gradients in blood and tissue.


Nitric Oxide Nitric Oxide Endothelial Dysfunction Vascular Wall Blood Flow Rate 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Donald G. Buerk
    • 1
  1. 1.Departments of Physiology and BioengineeringUniversity of PennsylvaniaPhiladelphia

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