Abstract
Computer simulations were performed based on a multiple chemical species convection-diffusion model with coupled biochemical reactions for oxygen (O2), nitric oxide (NO), superoxide (O2·-), peroxynitrite (ONOO-), nitrite (NO2 -) and nitrate (NO3 -) in cylindrical geometry with blood flow through a 30 ⎧m diameter arteriole. Steady state concentration gradients of all chemical species were predicted for different O2·- production rates, superoxide dismutase (SOD) concentrations, and blood flow rates. Effects of additional O2·- production from dysfunctional endothelial nitric oxide synthase (eNOS) were also simulated. The model predicts that convection is essential for characterizing O2 partial pressure gradients (PO2) in the bloodstream and surrounding tissue, but has little direct effect on NO gradients in blood and tissue.
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Buerk, D.G. (2009). Mathematical Modeling of The Interaction Between Oxygen, Nitric Oxide And Superoxide. In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_2
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DOI: https://doi.org/10.1007/978-0-387-85998-9_2
Publisher Name: Springer, Boston, MA
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