Abstract
The carotid body responds to both acute and more prolonged periods of lowered oxygen pressure. In the acute response, the decrease in oxygen pressure is coupled to increased afferent neural activity while the latter involves, at least in part, increase in the hypoxia inducible transcription factor HIF-1α. In this paper, we summarize evidence that both the acute changes in neural activity and the longer term adaptive changes linked to HIF-1α induction share the same oxygen sensor, mitochondrial cytochrome c oxidase.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wilson DF, Roy A, and Lahiri S. Immediate and long-term responses of the carotid body to high altitude. High Alt Med Biol 6: 97-111, 2005.
Baby SM, Roy A, Mokashi AM, and Lahiri S. Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor -1α and -1β in the rat carotid body and glomus cells. Histochem. Cell Biol. 120:343-352, (2003).
Roy A, Denys V, Baby SM, Mokashi A, Kubin L, and Lahiri S. Activation of HIF-1α mRNA by hypoxia and iron chelator in isolated rat carotid body. Neurosci Lett 363: 229-232, 2004.
Roy, A., Baby, S.M., Wilson, D.F., and Lahiri, S. Rat carotid body chemosensory discharge and glomus cell HIF-1a expression in vitro: Regulation by a common oxygen sensor. A.J.Physiol. –Reg. Integ. & Comp. Physiol.. 293(2): R829-36, 2007.
Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes. 55(1):1-12, 2006. Review.
Wilson DF, Mokashi A, Chugh D, Vinogradov S, Osanai S, and Lahiri S. The primary oxygen sensor of the cat carotid body is cytochrome a3 of the mitochondrial respiratory chain. FEBS Lett 351: 370-374, 1994.
Iturriaga R, Rumsey WL, Mokashi A, Spergel D, Wilson DF, and Lahiri S. In vitro perfusedsuperfused cat carotid body for physiological and pharmacological studies. J Appl Physiol. 70:1393-400, 1991.
Castor, L.N. and Chance, B. Photochemical action spectra of carbon monoxide –inhibited respiration. J. Biol. Chem. 217: 453-465, 1955.
Warburg O. Uber die Wirkung des Kohlenoxyds auf den Stoffwechsel der Hefe. Biochem J 177: 471-486, 1926.
Warburg, O. and Negelein, E. Über die Einfluss der Wellenlänge auf die Verteilung des Atmungsferments. (Absorptionsspektrum des Atmungsferments) Biochem. Z. 193, 339-346, 1928.
Wilson DF. Identifying oxygen sensors by their photochemical action spectra. Methods in Enz 381:690-703, 2004.
Mulligan E. and Lahiri S. Separation of carotid body chemoreceptor responses to O2 and CO2 by oligomycin and by antimycin A. Am J Physiol 242: C200-206, 1982.
Mulligan E. Lahiri S. Storey BT. Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation. J. Appl. Physiol: Resp. Env. & Exercise Physiol. 51(2): 438-46, 1981.
Semenza GL. HIF-1: mediator of physiological and pathological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
Roy A, Li J, Baby SM, Mokashi A, Buerk DG, and Lahiri S. Effects of iron-chelators on ion channels and HIF-1α in the carotid body. Respir Physiol & Neurobiol 141: 115-123, 2004.
Rumsey, WL, Iturriaga, R, Spergel, D, Lahiri, S, and Wilson, DF. Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body. Amer. J. Physiol. 261:C614-C622, 1991.
Allela, A. Williams FL, Bolene-Williams, C, and Katz, LN Interrelation between cardiac oxygen consumption and coronary blood flow. Am. J. Physiol. 183: 570-582, 1955.
Nuutinen EM, Nishiki K, Erecinska M, and Wilson DF. Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. Am J Physiol 243: H159-H169, 1982.
Nuutinen EM, Nelson D, Wilson DF, and Erecinska M. Regulation of coronary blood flow: effects of 2,4-dinitrophenol and theophylline. Amer J Physiol 244: H396-H405, 1983.
Lahiri S, Mokashi E, Mulligan E, and Nishino T. Comparison of aortic and carotid chemoreceptor responses to hypercapnia and hypoxia. J Appl Physiol 51(1): 55-61, 1981.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this paper
Cite this paper
Lahiri, S., Roy, A., Baby, S.M., Di Giulio, C., F. Wilson, D. (2009). Carotid Body Sensory Discharge And Glomus Cell Hif-1α Are Regulated By A Common Oxygen Sensor. In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_14
Download citation
DOI: https://doi.org/10.1007/978-0-387-85998-9_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-85997-2
Online ISBN: 978-0-387-85998-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)