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Carotid Body Sensory Discharge And Glomus Cell Hif-1α Are Regulated By A Common Oxygen Sensor

  • S. Lahiri
  • A. Roy
  • S. M. Baby
  • C. Di Giulio
  • D. F. Wilson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

Abstract

The carotid body responds to both acute and more prolonged periods of lowered oxygen pressure. In the acute response, the decrease in oxygen pressure is coupled to increased afferent neural activity while the latter involves, at least in part, increase in the hypoxia inducible transcription factor HIF-1α. In this paper, we summarize evidence that both the acute changes in neural activity and the longer term adaptive changes linked to HIF-1α induction share the same oxygen sensor, mitochondrial cytochrome c oxidase.

Keywords

Oxygen Pressure Coronary Blood Flow Carotid Body Oxygen Sensor Mitochondrial Oxidative Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • S. Lahiri
    • 1
  • A. Roy
    • 1
  • S. M. Baby
    • 1
  • C. Di Giulio
    • 2
  • D. F. Wilson
    • 3
  1. 1.Department of PhysiologyUniversity of PennsylvaniaPhiladelphia
  2. 2.Department of Basic and Applied Medical SciencesUniversity of ChietiItaly
  3. 3.Department of Biochemistry and BiophysicsUniversity of PennsylvaniaPhiladelphia

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