Multivariate Continuous Data
Most clinical trials are conducted to compare a treatment group with a control group on multiple endpoints. A classic example is chronic obstructive pulmonary disease (COPD), where there are a number of different types of potential endpoints (Pocock et al., 1987). Lung function tests are usually considered as key endpoints in COPD trials. However there are a large number of alternative lung function measurements that are believed to indicate efficacy in COPD (e.g. peak expiratory flow rate, forced expiratory volume, forced vital capacity, etc.). It therefore seems logical to consider multivariate approaches when assessing if the treatment improves the respiratory function compared with the control.
KeywordsChronic Obstructive Pulmonary Disease Ordinary Little Square Generalize Little Square Multivariate Normal Distribution Rejection Region
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