Development of Natural Killer cells
Natural killer cells are found in blood, lymphoid organs, liver, lungs and uterus, where they participate in several aspects of health and disease. During development, NK cells express a set of genes that encode for cell surface receptors, which interact with other cell surface molecules within the individual, between individuals and across genomes. Examples of the elements recognized by NK cells are self-MHC antigens during NK cell maturation, stress-inducible ligands during infections or tumour transformation, donor antigens on tissue grafts, paternal antigens at the feto—maternal interface and viral products. The nature of these interactions sets the threshold for NK cell activation, which in turn has downstream consequences on innate immunity and adaptive responses. Being endowed with these important recognition systems and instant effector function potential, NK cells have taken centre stage in modern medicine as they participate in infection, reproduction, transplantation, autoimmunity and cancer. This chapter reviews the basics of NK cell development, with an emphasis on murine cells.
KeywordsNatural Killer Cell Dolichos Biflorus Agglutinin Natural Killer Cell Development Ly49 Receptor CD56 Bright CD16
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