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Development of T Lymphocytes

  • Benjamin A. Schwarz
  • Avinash Bhandoola

Abstract

The goal of this chapter is to introduce readers to the cellular and molecular basis of T-cell differentiation. We have divided T-cell development into three major stages (early T-lineage development, β or γδ selection, positive and negative selection). These correlate with specific subsets of thymocytes (ETP-DN3, DN3-DP, DP-SP thymocytes), specific locations within the thymus (cortex, subcapsular zone, cortex and medulla), T-cell receptor rearrangement events (no functional rearrangements, β or γδ rearrangements, α rearrangements), and lineage fate decisions (T-lineage commitment, αβ vs. γδ, CD4 vs. CD8). Models for each developmental decision and the molecular players are presented.

Keywords

Negative Selection Recombination Signal Sequence Subcapsular Zone Tcrb Locus Thymus Settling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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