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Targeting Signal Transduction Pathways in Hematopoietic Disorders

  • Li Zhou
  • Amit Verma

Abstract

Hematopoiesis is the process during which pluripotent stem cells give rise to lineage committed progenitors that differentiate into mature erythroid, myeloid, and lymphoid cells. This is a finely regulated process that is required for optimal maintenance of peripheral blood counts. Alterations in hematopoiesis can lead to a variety of bone marrow failure syndromes and hematological malignancies. Treatment of these diseases requires a detailed study of pathogenic mechanisms that lead to hematopoietic failure.

Keywords

Tumor Necrosis Factor Aplastic Anemia Myelodysplastic Syndrome Stem Cell Factor Hematopoietic Progenitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Li Zhou
    • 1
  • Amit Verma
    • 1
  1. 1.Albert Einstein College of MedicineBronxUSA

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