Tropomyosin pp 110-123 | Cite as

Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


Smooth muscle contraction is due to the interaction of myosin filaments with thin filaments. Thin filaments are composed of actin, tropomyosin, caldesmon and calmodulin in ratios 14∶2∶1∶1. Tissue specific isoforms of α and β tropomyosin are expressed in smooth muscle. Compared with skeletal muscle tropomyosin, the cooperative activation of actomyosin is enhanced by smooth muscle tropomyosin: cooperative unit size is 10 and the equilibrium between on and off states is shifted towards the on state. The smooth muscle-specific actin-binding protein caldesmon, together with calmodulin regulates the activity of the thin filament in response to Ca2+. Caldesmon and calmodulin control the tropomyosin-mediated transition between on and off activity states.


Smooth Muscle Actin Binding Actin Monomer Smooth Muscle Myosin Actomyosin ATPase 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Cardiac Medicine, National Heart and Lung InstituteImperial College LondonLondonUK
  2. 2.Department of BiochemistryUniversity of LeicesterLeicesterUK

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