Tropomyosin pp 43-59 | Cite as

Tropomyosin Gene Expression in Vivo and in Vitro

  • Galina Schevzov
  • Geraldine O’Neill
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


The evolution from unicellular to multicellular organisms of increasing complexity is paralleled by increased numbers of tropomyosin (Tm) genes and increasing numbers of isoforms encoded by each gene. The regulation of Tm isoform expression is intimately associated with the morphological changes that take place during development and cell differentiation. The tissue- and cell-specific Tm expression patterns are regulated at multiple levels, allowing precise spatial and temporal regulation of Tm expression. In this chapter, we review the Tm isoform expression pattern during differentiation of different tissue types and from this data infer some general principles regarding Tm expression patterns during differentiation. Finally, we review the mechanisms that account for the highly regulated repertoire of Tm isoform expression.


Granulosa Cell Actin Cytoskeleton Serum Response Factor Lens Cell Nemaline Myopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Oncology Research UnitThe Children’s Hospital at WestmeadWestmeadAustralia
  2. 2.Discipline of Paediatrics and Child HealthUniversity of SydneySydneyAustralia

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