Tropomyosin pp 27-42 | Cite as

Tropomyosin Exons as Models for Alternative Splicing

  • Clare Gooding
  • Christopher W. J. SmithEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


Three of the four mammalian tropomyosin (Tm) genes are alternatively spliced, most commonly by mutually exclusive selection from pairs of internal or 3′ end exons. Alternative splicing events in the TPM1, 2 and 3 genes have been analysed experimentally in various levels of detail. In particular, mutually exclusive exon pairs in the βTm (TPM2) and αTm (TPM1) genes are among the most intensively studied models for striated and smooth muscle specific alternative splicing, respectively. Analysis of these model systems has provided important insights into general mechanisms and strategies of splicing regulation.


Alternative Splice Splice Site Branch Point Alternative Splice Event Polypyrimidine Tract Binding 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of CambridgeCambridgeUK

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