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Tropomyosin pp 293-298 | Cite as

Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology

  • Peter Gunning
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)

Abstract

There is a growing awareness of the role of tropomyosin in the regulation of the actin filament. Work in the field is increasingly directed at understanding the mechanisms of function at both a molecular and atomic level and developing therapeutic strategies to treat tropomyosin-based pathology. This chapter highlights unresolved issues that cross the boundaries between individual chapters and are likely to be fertile areas of research in the future.

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References

  1. 1.
    Alberts B, Bray D, Lewis J et al. Molecular Biology of the Cell, 3rd Ed. Garland Publishing Inc., New York: 1994; Fig 16–79.Google Scholar
  2. 2.
    Ayscough KR. In vivo functions of actin-binding proteins. Curr Opin Cell Biol 1998; 10:102–111.PubMedCrossRefGoogle Scholar
  3. 3.
    Craig SW, Pardo JV. Gamma actin, spectrin and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to-sarcolemma attachment sites. Cell Motil 1983; 3:449–462.PubMedCrossRefGoogle Scholar
  4. 4.
    Kee AJ, Schevzov G, Nair-Shalliker V et al. Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy. J Cell Biol 2004; 166:685–696.PubMedCrossRefGoogle Scholar
  5. 5.
    Lubit BW. Association of beta-cytoplasmic actin with high concentrations of acetylcholine receptor (AChR) in normal and anti-AChR-treated primary rat muscle cultures. J Histochem Cytochem 1984; 32:973–981.PubMedGoogle Scholar
  6. 6.
    Schevzov G, Lloyd C, Hailstones D et al. Differential regulation of tropomyosin isoform organisation and gene expression in response to altered actin gene expression. J Cell Biol 1993; 121:811–821.PubMedCrossRefGoogle Scholar
  7. 7.
    Wong K, Wessels D, Krob SL et al. Forced expression of a dominant-negative chimeric tropomyosin causes abnormal motile behaviour during cell division. Cell Motil Cytoskel 2000; 45:121–132.CrossRefGoogle Scholar
  8. 8.
    Vlahovich N, Schevzov G, Nair-Shalliker V et al. Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and disease muscle. Cell Motil Cytoskel 2008; 65:73–85.CrossRefGoogle Scholar
  9. 9.
    Houle F, Rousseau S, Morrice N et al. Extracellular signal-regulated kinase mediates phosporylation of tropomyosin-1 to promote cytoskeleton remodelling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell 2003; 14:1418–1432.PubMedCrossRefGoogle Scholar
  10. 10.
    Naga Prasad SV, Jayatilleke A, Madamanchi A et al. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. Nat Cell Biol 2005; 7:785–796.PubMedCrossRefGoogle Scholar
  11. 11.
    Somara S, Pang H, Bitar KN. Agonist-induced association of tropomyosin with the protein kinase C-α in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 2005; 288:G268–G276.PubMedCrossRefGoogle Scholar
  12. 12.
    Gunning P, O’Neill G, Hardeman E. Tropomyosin-based regulation of the actin cytoskeleton in time and space. Physiol Rev 2008; 88:1–35.PubMedCrossRefGoogle Scholar
  13. 13.
    Lehman W, Hatch V, Korman V et al. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. J Mol Biol 2000; 302:593–606.PubMedCrossRefGoogle Scholar
  14. 14.
    Prasad GL, Fuldner RA, Cooper HL. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc Natl Acad Sci USA 1993; 90:7039–7043.PubMedCrossRefGoogle Scholar
  15. 15.
    Boyd J, Risinger JI, Wiseman RW et al. Regulation of microfilament organization and anchorage-independent growth by tropomyosin1. Proc Natl Acad Sci USA 1995; 92:11534–11538.PubMedCrossRefGoogle Scholar
  16. 16.
    Gimona M, Kazzaz JA, Helfman DM. Forced expression of tropomyosin 2 or 3 in v-ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proc Natl Acad Sci USA 1996; 93:9618–9623.PubMedCrossRefGoogle Scholar
  17. 17.
    O’Neill GM, Stehn J, Gunning PW. Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton. Seminars Cancer Biol 2008; 18:35–44.CrossRefGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Peter Gunning
    • 1
  1. 1.Oncology Research Unit, Department of Pharmacology, School of Medical SciencesUniversity of New South WalesSydneyAustralia

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