Tropomyosin pp 223-231 | Cite as

Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments

  • Uno Lindberg
  • Clarence E. Schutt
  • Robert D. Goldman
  • Maria Nyåkern-Meazza
  • Louise Hillberg
  • Li-Sophie Zhao Rathje
  • Staffan Grenklo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


The state of actin depends intimately on its interaction partners in eukaryotic cells. Classically, the cooperative force-generating acto-myosin couple is turned off and on by the calcium-dependent binding and release of tropomyosin molecules. The situation with nonmuscle cells appears to be much more complicated, with tropomyosin isoforms regulating the kinds of tension-producing and stress-bearing structures formed of actin filaments. The polymerization of even the shortest gelsolin-capped filaments is efficiently promoted by the binding of tropomyosin, for example, a process that might occur all the way out to the leading edges of advancing cells. Recently, multimers of tropomyosin have been discovered that appear to be assembly intermediates, formed from identical tropomyosin molecules, which act as ready pools of tropomyosin during the catalytic formation of lamellipodia and filopodia. Remarkably, these multimers apparently reform during the disassembly of cellular actin-containing structures. The existence of these recyclable, tropomyosin isoform-specific structures suggests how cells prevent nonproductive association of non-identical, but closely similar, tropomyosin isoforms.


Actin Filament Actin Polymerization Actin Binding Protein Branch Formation Assembly Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Uno Lindberg
    • 1
  • Clarence E. Schutt
    • 2
  • Robert D. Goldman
    • 3
  • Maria Nyåkern-Meazza
    • 1
  • Louise Hillberg
    • 1
  • Li-Sophie Zhao Rathje
    • 1
  • Staffan Grenklo
    • 1
  1. 1.Department of Microbiology, Tumor Biology and Cell BiologyKarolinska InstitutetStockholmSweden
  2. 2.Department of ChemistryPrinceton UniversityPrincetonUSA
  3. 3.Department of Cell and Molecular Biology Feinberg School of MedicineNorthwestern UniversityChicagoUSA

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