Tropomyosin pp 168-186 | Cite as

Tropomyosin Function in Yeast

  • David Pruyne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


Tropomyosins were discovered as regulators of actomyosin contractility in muscle cells, making yeasts and other fungi seem unlikely to harbor such proteins. Fungal cells are encased in a rigid cell wall and do not engage in the same sorts of contractile shape changes of animal cells. However, discovery of actin and myosin in yeast raised the possibility for a role for tropomyosin in regulating their interaction. [1,2], Through abiochemical search, fungal tropomyosins were identified with strong similarities to their animal counterparts in terms of protein structure and physical properties. Two particular fungi, the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe have provided powerful genetic systems for studying tropomyosins in nonmetazoans. In these yeasts, tropomyosins associate with subsets of actin filamentous structures. Mutational studies of tropomyosin genes and biochemical assyas of purified proteins point to roles for these proteins as factors that stabilize actin filaments, promote actin-based structures of particular architecture and help maintain distinct biochemical identities among different filament populations. Tropomyosin-enriched filaments are the cytoskeletal structures that promote the major cell shape changes of these organisms: polarized growth and cell division.


Secretory Vesicle Schizosaccharomyces Pombe Myosin Versus Division Site Actin Cable 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • David Pruyne
    • 1
  1. 1.Department of Molecular Biology and GeneticsCornell UniversityIthacaUSA

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