Tropomyosin pp 132-142 | Cite as

The Role of Tropomyosin in Heart Disease

  • David F. Wieczorek
  • Ganapathy Jagatheesan
  • Sudarsan Rajan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 644)


Cardiovascular disease is the number one cause of mortality in the Western world, with heart failure representing one of the fastest growing subgroups over the past decade. Heart failure, the progressive loss of cardiac contractile performance resulting in an inability to pump an adequate supply of systemic blood, affects an estimated 5 million Americans with estimated medical costs of $21–$50 billion per year1. A number of common disease disease stimuli can induce heart failure, including hypertension, myocardial infarction, ischemia associated with coronary artery disease, congenital malformation, familial hypertrophic and dilated cardiomyopathies and diabetic cardiomyopathy. Systolic and diastolic dysfunction is common in patients suffering from coronary artery disease and hypertension and is a main cause of heart failure. Hypertrophic growth of cardiomyocytes also occurs in many forms of heart failure and may contribute to the pathogenesis of the failure state2.


Dilate Cardiomyopathy Myosin Heavy Chain Hypertrophic Cardiomyopathy Calcium Sensitivity Familial Hypertrophic Cardiomyopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • David F. Wieczorek
    • 1
  • Ganapathy Jagatheesan
    • 1
  • Sudarsan Rajan
    • 1
  1. 1.Department of Molecular Genetics, Biochemistry and MicrobiologyUniversity of Cincinnati Medical CenterCincinnatiUSA

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