Vibrational Spectroscopic Methods for Quantitative Analysis

  • Frederick H. Long


Spectroscopic methods such as NIR, Fourier transform infrared, and Raman are becoming increasing important in pharmaceutical research and manufacturing. This chapter reviews both quantitative and qualitative applications of spectroscopic analysis for pharmaceutical products. Several applications of these technologies to stability testing are discussed.


Partial Little Square Partial Little Square Regression Partial Little Square Model Standard Reference Material Partial Little Square Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Griffiths P, DeHaseth J (2007) Fourier transform infrared spectroscopy. 2nd edn John Wiley & Sons, Chichester.Google Scholar
  2. 2.
    Sasić S (ed) (2008) Pharmaceutical applications of Raman spectroscopy. Wiley Interscience, Sandwich.Google Scholar
  3. 3.
    US Food and Drug Administration (2004) Guidance for industry process analytical technology.Google Scholar
  4. 4.
    International Committee on Harmonization (2005) Pharmaceutical development Q8.Google Scholar
  5. 5.
    International Committee on Harmonization (2007) Pharmaceutical development annex to Q8.Google Scholar
  6. 6.
    Atkins P (1996) Physical chemistry. 5th edn Freeman, p 543.Google Scholar
  7. 7.
    Brown S, Claybourn M, Fawcett V, Rodger C (2007) Optimizing Raman spectroscopy to quantify polymorphic forms of a drug molecule. Am Pharm Rev vol 10, 6:58–67.Google Scholar
  8. 8.
    Chan K L A, Fleming O S, Kazarian S G, D Vassou, Chryssikos G D, Gionis V (2004) Polymorphism and devitrification of nifedipine under controlled humidity: a combined FT-Raman, IR, and Raman microscopic investigation. J Raman Spectrosc 35:353–359.CrossRefGoogle Scholar
  9. 9.
    Hausman D S, Cambron R T, Sakr A (2005) Application of on-line Raman spectroscopy for characterizing relationships between drug hydration state and tablet physical stability. Int J Pharm 299:19–33.CrossRefPubMedGoogle Scholar
  10. 10.
    Long F (2007) The role of NIR spectroscopy in meeting the PAT challenge. Tablets and Capsules issue 2.Google Scholar
  11. 11.
    Balss K, Long F, Veselov V, Akerman E, Papandreou G, Maryanoff C (2008) multivariate analysis applied to the study of spatial distributions found in drug-eluting stent coatings by confocal Raman microscopy. Anal Chem 80:4853–4859.CrossRefPubMedGoogle Scholar
  12. 12.
    El Hagrasy A, Chang S-Y, Desai D, Kiang S (2006) Application of Raman spectroscopy for quantitative in-line monitoring of tablet coating. Am Pharm Rev 9:40–45.Google Scholar
  13. 13.
    Wold S, Josefson M (2000) Multivariate analysis of analytical data. In: Meyers R (ed) Encyclopedia of analytical chemistry. John Wiley & Sons, Chichester, pp 9710–9736.Google Scholar
  14. 14.
    Esbensen, K (2002) Multivariate data analysis – in practice. CAMO Process AS, Oslo.Google Scholar
  15. 15.
    Ritchie G (2002) Software shootout data. International Diffuse Reflection Conference, Chambersburg.Google Scholar
  16. 16.
    Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J, Wikström, Wold S (2006) Multi- and megavariate data analysis. Umetrics AB, Sweden.Google Scholar
  17. 17.
    Siesler H, Ozaki Y, Kawata Y, Heise H (2002) Near-infrared spectroscopy: principles, instruments, applications. John Wiley & Sons, New York.Google Scholar
  18. 18.
    US Pharmacopoeia Analytical instrument qualification, chapter <1058≫.Google Scholar
  19. 19.
    US Pharmacopoeia Near IR spectroscopy, chapter <1119≫.Google Scholar
  20. 20.
    ASTM (2007) Standard guide for Raman spectrometer calibration, E1840-96.Google Scholar
  21. 21.
    US Pharmacopoeia Raman spectroscopy, chapter <1120>.Google Scholar
  22. 22.
    Miller J, Miller J (2000) Statistics and chemometrics for analytical chemistry. Prentice Hall, Harlow, p 137.Google Scholar
  23. 23.
    Peru D (2008) PAT reducing the cost of quality in consumer product manufacturing. Am Pharm Rev 11:97–102.Google Scholar
  24. 24.
    Barnes S, Gillian J, Diederich A, Burton D, Ertl D (2008) In process monitoring of polymorphic form conversion by Raman spectroscopy and turbidity measurements. Am Pharm Rev vol 11, 3:80–85.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Spectroscopic SolutionsRandolphUSA

Personalised recommendations