Abstract
During the last decade, intensive research efforts have been expended to develop solid-state magnetic sensors for applications such as biomolecular sensing and single molecule detection. This chapter reviews sensors proposed thus far, including (a) GMR and spin valve sensors based on the giant magnetoresistance (GMR) effect; (b) magnetic tunnel junction (MTJ) sensors based on tunneling magnetoresistance (TMR); (c) anisotropic magnetoresistance (AMR) ring sensors and planar Hall effect sensors based on the AMR effect; (d) Hall sensors based on the classical Hall effect; and (e) giant magnetoimpedance (GMI) sensors based on the frequency-dependent variation of the skin depth in magnetic wires with field. Two different types of sensors are highlighted: the ones with large sensing areas (hundreds of μm2) intended to provide statistical counting of a large number of magnetic micro- or nanoparticles and the others with micro- or submicrometer-sized sensing areas that focus on single particle detection.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
Micrometer-sized ring sensors for bioapplications have been also reported more recently by the group from University of Cambridge [31]. Although these devices are geometrically similar, they are fabricated from a sandwich structure containing hard ferromagnet/normal metal/soft ferromagnet (Co/Cu/Py, for example) so that their operation is based on the GMR effect rather than AMR.
- 2.
Similar sensors were also examined by the group from NRL [27].
References
Abels, J. A., et al.: Single-molecule measurements of the persistence length of double-stranded RNA. Biophys. J. 88, 2737–2744 (2005)
Baibich, M. N., et al.: Giant magnetoresistance of (001)Fe/(001)Cr magnetic superlattices. Phys. Rev. Lett. 61, 2472–2475 (1988)
Baselt, D. R., et al.: A biosensor based on magnetoresistance technology. Biosens. Bioelectron. 13, 731–739 (1998)
Besse, P. A., et al.: Detection of single magnetic microbead using using a miniaturized silicon Hall sensor. Appl. Phys. Lett. 80, 4199–4201 (2002)
Binasch, G., et al.: Enhanced magnetoresistance in layered magnetic structures with antiferromagnetic interlayer exchange. Phys. Rev. B 39, 4828–4830 (1989)
Boero, G., et al.: Micro-Hall devices: performances, technologies and applications. Sens. Actuators A 106, 314–320 (2003)
Butler, W. H., et al.: Spin-dependent tunneling conductance of Fe|MgO|Fe sandwiches. Phys. Rev. B 63, 054416–054427 (2001)
Cardoso, F. A., et al.: Diode/magnetic tunnel junction cell for fully scalable matrix based biochip. J. Appl. Phys. 99, 08B307–08B309 (2006)
Chiriac, H., et al.: Microwire array for giant magneto-impedance detection of magnetic particles for biosensor prototype. J. Magn. Magn. Mater. 311, 425–428 (2007)
Damsgaard, C. D., et al.: Exchange-biased planar Hall effect sensor optimized for biosensor applications. J. Appl. Phys. 103, 07A302 (2008)
Djayaprawira, D. D., et al.: 230% room-temperature magnetoresistance in CoFeB/MgO/ CoFeB magnetic tunnel junctions. Appl. Phys. Lett. 86, 092502 (2005)
Ejsing, L., et al.: Planar Hall effect sensors for magnetic micro- and nanobead detection. Appl. Phys. Lett. 84, 4729–4731 (2004)
Ejsing, L., et al.: Magnetic micro-bead detection using the planar Hall effect. J. Magn. Magn. Mater. 293, 677–684 (2005)
Ferreira, H. A., et al.: Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited). J. Appl. Phys. 93, 7281–7286 (2003)
Ferreira, H. A., et al.: Rapid DNA hybridization based on ac field focusing of magnetically labeled target DNA. Appl. Phys. Lett. 87, 013901 (2005)
Ferreira, H. A., et al. Magnetoresistive DNA-chips based on ac field focusing of magnetic labels. J. Appl. Phys. 99, 08P105–08P107 (2006)
Fonnum, G., et al.: Characterization of Dynabeads® by magnetization measurements and Mössbauer spectroscopy. J. Magn. Magn. Mater. 293, 41–47 (2005)
Freitas, P. P., et al.: Magnetoresistive sensors. J. Phys.: Condens. Mat. 19, 165221 (2007)
Graham, D. L., et al.: Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnol. Appl. J. Appl. Phys. 91, 7786–7788 (2002)
Graham, D. L., et al.: High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors. Biosens. Bioelectron. 18, 483–488 (2003)
Hall, E. D.: On a new action of the magnet on electric currents. Am. J. Math. 2, 287–292 (1879)
Hauser, H., et al.: Giant magnetoimpedance sensors. IEEE Instrum. Meas. Mag. 4, 28–32 (2001)
Kroemer, H.: The 6.1 Å family (InAs, GaSb, AlSb) and its heterostructures: a selective review. Physica E 20, 196–203 (2004)
Kurlyandskaya, G. V., et al.: Giant magnetoimpedance-based sensitive element as a model for biosensor. Appl. Phys. Lett. 82, 3053–3055 (2003)
Kurlyandskaya, G. and Levit, V.: Magnetic Dynabeads detection by sensitive element based on giant magnetoimpedance. Biosens. Bioelectron. 20, 1611–1616 (2005)
Julliere, M.: Tunneling between ferromagnetic films. Phys. Lett. A 54, 225–226 (1975)
Landry, G., et al.: Characterization of single magnetic particles with In As quantum-well Hall devices. Appl. Phys. Lett. 85, 4693–4695 (2004)
Li, G., et al.: Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications. J. Appl. Phys. 93, 7557–7559 (2003)
Li, G., et al.: Model and experiment of detecting multiple magnetic nanoparticles as biomolecular labels by spin valve sensors. IEEE Trans. Magn. 40, 3000–3002 (2004)
Li, G., et al.: Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications. Sens. Actuators A 126, 98–106 (2006)
Liandro, J., et al.: Quantitative digital detection of magnetic beads using pseudo-spin valve rings for multiplexed bioassays. Appl. Phys. Lett. 91, 203904 (2007)
Mathon, J. and Umerski, A.: Theory of tunneling magnetoresistance of an epitaxial Fe/MgO/Fe(001) junction. Phys. Rev. B 63, 220403–220406 (2001)
Megens, M. and Prins, M.: Magnetic biochips: a new option for sensitive diagnostics. J. Magn. Magn. Mater. 293, 702–708 (2005)
Meservey, R. and Tedrow, P. M.: Spin-polarized electron tunneling. Phys. Rep. 238, 173–243 (1994)
Mihajlović, G., et al.: Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor. Appl. Phys. Lett. 87, 112502 (2005)
Mihajlović, G., et al.: Submicrometer hall sensors for superparamagnetic nanoparticle detection. IEEE Trans. Magn. 43, 2400–2402 (2007a)
Mihajlović, G., et al.: InAs quantum well Hall devices for room-temperature detection of single magnetic biomolecular labels. J. Appl. Phys. 102, 034506 (2007b)
Millen, R. L., et al.: Giant magnetoresistive sensors and superparamagnetic nanoparticles: a chip scale detection strategy for immunosorbent assays. Anal. Chem. 77, 6581–6587 (2005)
Miller, M. M., et al.: A DNA Array sensor utilizing magnetic microbeads and magnetoelectronic detection. J. Magn. Magn. Mater. 225, 138–144 (2001)
Miller, M. M., et al.: Detection of a micron-sized magnetic sphere using a ring-shaped anisotropic magnetoresistance-based sensor: A mode; for a magnetoresistance-based biosensor. Appl. Phys. Lett. 81, 2211–2213 (2002)
Mulvaney, S. P., et al.: Rapid, femtomolar bioassays in complex matrices combining microfluidics and magnetoelectronics. Biosens. Bioelectron. 23, 191–200 (2007)
Parkin, S. S. P., et al.: Giant tunneling magnetoresistance at room temperature with MgO (100) tunnel barriers. Nat. Mater. 3, 862–867 (2004)
Rife, J. C., et al: A design and performance of GMR sensors for the detection of magnetic microbeads in biosensors. Sens. Actuators A 107, 209–218 (2003)
Sandhu, A., et al.: High sensitivity InSb ultra-thin film micro-hall sensors for bioscreening applications. Jpn. J. Appl. Phys. 43, L868–L870 (2004)
Sandhu, A. and Handa, H.: Practical Hall sensors for biomedical instrumentation. IEEE Trans. Magn. 41, 4123–4127 (2005)
Schotter, J., et al.: Comparison of a prototype magnetoresistive biosensor to standard fluorescent DNA detection. Biosens. Bioelectron. 19, 1149–1156 (2004)
Shen, W., et al.: In situ detection of single micron-sized magnetic beads using magnetic tunnel junction sensors. Appl. Phys. Lett. 86, 253901 (2005)
Shen, W., et al.: Detection of DNA labeled with magnetic nanoparticles using MgO-based magnetic tunnel junction sensors. J. Appl. Phys. 103, 07A306 (2008)
Smit, J.: Magnetoresistance of ferromagnetic metals and alloys at low temperatures. Physica (Amsterdam) 17, 612–627 (1951)
Smith, C. H. and Schneider, R. W.: Low-field magnetic sensing with GMR sensors. NVE Research and Development Papers & Presentations. http://www.nve.com/Downloads/lowfield.pdf (1999). Accessed 10 January 2008
Tamanaha, C. R. and Whitman, L. J.: Magnetic labeling and detection of biomolecules. In: Buschow, K. H. J. (ed.) Encyclopedia of Materials: Science and Technology. Elsevier, Amsterdam (2004)
Thomson, W.: On the electro-dynamic qualities of metals: effects of magnetization on the electric conductivity of nickel and of iron. Proc. R. Soc London 8, 546 (1857)
Togawa, K., et al.: Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensors. J. Appl. Phys. 99, 08P103 (2006)
Tondra, M., et al.: Model for detection of immobilized superparamagnetic nanosphere assay labels using giant magnetoresistive sensors. J. Vac. Sci. Technol. A 18, 1125–1129 (2000)
Wang, D., et al.: 70% TMR at room temperature for SDT sandwich junctions with CoFeB as free and reference layers. IEEE Trans. Magn. 40, 2269–2271 (2004)
Wang, S. X., et al.: Towards a magnetic microarray for sensitive diagnostics. J. Magn. Magn. Mater. 225, 731–736 (2005)
Wood, D. K., et al.: Submicron giant magnetoresistive sensors for biological applications. Sens. Actuators A 120, 1–6 (2005)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Mihajlović, G., von Molnár, S. (2009). Solid-State Magnetic Sensors for Bioapplications. In: Liu, J., Fullerton, E., Gutfleisch, O., Sellmyer, D. (eds) Nanoscale Magnetic Materials and Applications. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85600-1_23
Download citation
DOI: https://doi.org/10.1007/978-0-387-85600-1_23
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-85598-1
Online ISBN: 978-0-387-85600-1
eBook Packages: EngineeringEngineering (R0)