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Recent Advances in Traditional Medicines and Dietary Supplements

  • Jeevan Prasain
  • Stephen Barnes
Chapter

Abstract

Traditional medicines and dietary supplements continue to be used in the search for bioactive agents that maintain health and prevent disease. Individual compounds are being isolated and tested, as is the synergism offered by the variety of compounds in botanicals and supplements. Establishing the composition and quality control of botanicals and supplements is essential in order to carry out clinical trails. Interactions between botanicals and conventinal therapeutics must also be carefully considered. Increasing numbers of investigators are applying–Omic technologies to pursue the mechanisms of action of botanicals.

Keywords

Natural Killer Cell Dietary Supplement Traditional Medicine Grape Seed Extract Bitter Melon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J. Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience. 2006;142:941–52.PubMedCrossRefGoogle Scholar
  2. Barnes S, Prasain JK. Current progress in the use of traditional medicines and nutraceuticals. Curr Opin Plant Biol. 2005;8:324–8.PubMedCrossRefGoogle Scholar
  3. Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutr. 2008; 87:476S–80S.PubMedGoogle Scholar
  4. Béliveau R, Gingras D. Role of nutrition in preventing cancer. Can Fam Physician. 2007;53:1905–11.PubMedGoogle Scholar
  5. Carlson S, Peng N, Prasain JK, Wyss JM. Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females. Gend Med. 2008;5 Suppl A:S76–90.PubMedCrossRefGoogle Scholar
  6. Cefalu WT, Ye J, Wang ZQ. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Endocr Metab Immune Disord Drug Targets. 2008;8:78–81.PubMedCrossRefGoogle Scholar
  7. Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005;100:72–9.PubMedCrossRefGoogle Scholar
  8. Clouatre DL. Kava kava: examining new reports of toxicity. Toxicol Lett. 2004;150:85–96.PubMedCrossRefGoogle Scholar
  9. Dahan K, Fennal M, Kumar NB. Lycopene in the prevention of prostate cancer. J Soc Integr Oncol. 2008;6:29–36.PubMedGoogle Scholar
  10. Dascalu A, Sievenpiper JL, Jenkins AL, Stavro MP, Leiter LA, Arnason JT, Vuksan V. Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individuals. Can J Physiol Pharmacol. 2007;85:856–64.PubMedCrossRefGoogle Scholar
  11. Dennehy C. Need for additional, specific information in studies with echinacea. Antimicrob Agents Chemother. 2001;45:369–70.PubMedCrossRefGoogle Scholar
  12. Deshane J, Chaves L, Sarikonda KV, Isbell S, Wilson L, Kirk M, Grubbs C, Barnes S, Meleth S, Kim H. Proteomics analysis of rat brain protein modulations by grape seed extract. J Agric Food Chem. 2004;52:7872–83.PubMedCrossRefGoogle Scholar
  13. Dodge HH, Zitzelberger T, Oken BS, Howieson D, Kaye J. A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline. Neurology. 2008;70:1809–17.PubMedCrossRefGoogle Scholar
  14. Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561–6.PubMedCrossRefGoogle Scholar
  15. Druker BJ, Guilhot F, O’Brien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, Cervantes F, Hochhaus A, Powell BL, Gabrilove JL, Rousselot P, Reiffers J, Cornelissen JJ, Hughes T, Agis H, Fischer T, Verhoef G, Shepherd J, Saglio G, Gratwohl A, Nielsen JL, Radich JP, Simonsson B, Taylor K, Baccarani M, So C, Letvak L, Larson RA, IRIS Investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355: 2408–17.PubMedCrossRefGoogle Scholar
  16. Farnsworth NR. Screening plants for new medicines. Chapter 9. In: EO Wilson (Ed), Biodiversity, Washington, DC: National Academy Press, 1988.Google Scholar
  17. Farnsworth NR, Morris RW. Higher plants – the sleeping giant of drug development. Am J Pharm Sci Support Public Health. 1976;148:46–52.PubMedGoogle Scholar
  18. Feng X, Liu X, Luo Q, Liu BF. Mass spectrometry in systems biology: an overview. Mass Spectrom Rev. 2008 July 17.Google Scholar
  19. Gardiner P, Phillips R, Shaughnessy AF. Herbal and dietary supplement – drug interactions in patients with chronic illnesses. Am Fam Physician. 2008;77:73–8.PubMedGoogle Scholar
  20. Garg R, Ramchandani A, Maru G. Curcumin decreases 12–0-tetradecanoylphorbol-13-acetate-induced protein kinase C translocation to modulate downstream targets in mouse skin. Carcinogenesis. 2008 May 13 [Epub ahead of print]Google Scholar
  21. Geil P, Shane-McWhorter L. Dietary supplements in the management of diabetes: potential risks and benefits. J Am Diet Assoc. 2008;108: S59–65.PubMedCrossRefGoogle Scholar
  22. Goldman RD, Rogovik AL, Lai D, Vohra S. Potential interactions of drug-natural health products and natural health products-natural health products among children. J Pediatr. 2008;152:521–6.PubMedCrossRefGoogle Scholar
  23. Graening T, Schmalz H-G. Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry. Angew. Chem. Int. Ed. 2004;43;3230.CrossRefGoogle Scholar
  24. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Khan IA, Shah A. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther. 2005;77:415–26.PubMedCrossRefGoogle Scholar
  25. Gurley BJ, Swain A, Hubbard MA, Williams DK, Barone G, Hartsfield F, Tong Y, Carrier DJ, Cheboyina S, Battu SK. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John’s wort, and Echinacea. Mol Nutr Food Res. 2008 Jan 23 [Epub ahead of print].Google Scholar
  26. Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel G. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol. 2005;21:257–64.PubMedCrossRefGoogle Scholar
  27. Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003;78:544S–551S.PubMedGoogle Scholar
  28. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Res. 2007;67:8396–405.PubMedCrossRefGoogle Scholar
  29. Igel M, Sudhop T, von Bergmann K. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). Eur J Clin Pharmacol. 2001;57:357–64.PubMedCrossRefGoogle Scholar
  30. Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007;255: 170–81.PubMedCrossRefGoogle Scholar
  31. Jones PJ, Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY, Parsons WE. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res. 2000;41:697–705.PubMedGoogle Scholar
  32. Kang YJ. Herbogenomics: from traditional Chinese medicine to novel therapeutics. Exp Biol Med (Maywood). 2008 June 5 [Epub ahead of print].Google Scholar
  33. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal. 2008;10:475–510.PubMedCrossRefGoogle Scholar
  34. Keung WM, Klyosov AA, Vallee BL. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci USA. 1997;94:1675–9.PubMedCrossRefGoogle Scholar
  35. Kuehne Martin E.; Matson Patricia A. Bornmann, William G. Enantioselective syntheses of vinblastine, leurosidine, vincovaline and 20’-epi-vincovaline. J Org Chem 1991;56:513–28.CrossRefGoogle Scholar
  36. Kussmann M, Raymond F, Affolter M. OMICS-driven biomarker discovery in nutrition and health. J Biotechnol. 2006;124:758–87.PubMedCrossRefGoogle Scholar
  37. Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J, Ungvari Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem. 2006;13:989–96.PubMedCrossRefGoogle Scholar
  38. Lawson LD, Gardner CD. Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem. 2005;53: 6254–61.PubMedCrossRefGoogle Scholar
  39. Lawson LD, Wang ZJ. Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity. J Agric Food Chem. 2001;49:2592–9.PubMedCrossRefGoogle Scholar
  40. Leach AR, Hann MM. The in silico world of virtual libraries. Drug Discov Today. 2000;5:326–336.PubMedCrossRefGoogle Scholar
  41. Luo Y. Ginkgo biloba neuroprotection: Therapeutic implications in Alzheimer’s disease. J Alzheimers Dis. 2001;3:401–407.PubMedGoogle Scholar
  42. McCarney R, Fisher P, Iliffe S, van Haselen R, Griffin M, van der Meulen J, Warner J. Ginkgo biloba for mild to moderate dementia in a community setting: a pragmatic, randomised, parallel-group, double-blind, placebo-controlled trial. Int J Geriatr Psychiatry. 2008 June 9 [Epub ahead of print].Google Scholar
  43. McKenna DJ. Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges. Pharmacol Ther. 2004;102:111–29.PubMedCrossRefGoogle Scholar
  44. Meezan E, Meezan EM, Jones K, Moore R, Barnes S, Prasain JK. Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. J Agric Food Chem. 2005;53:8760–7.PubMedCrossRefGoogle Scholar
  45. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712–6.PubMedCrossRefGoogle Scholar
  46. Napryeyenko O, Borzenko I. GINDEM-NP Study Group. Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung. 2007;57:4–11.PubMedGoogle Scholar
  47. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70:461–77.PubMedCrossRefGoogle Scholar
  48. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. J Nat Prod. 2003;66:1022–37.PubMedCrossRefGoogle Scholar
  49. Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, et al. Total synthesis of taxol. Nature. 1994;367:630–4.PubMedCrossRefGoogle Scholar
  50. O’Keefe JH, Gheewala NM, O’Keefe JO. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol. 2008;51:249–55.PubMedCrossRefGoogle Scholar
  51. Patch CS, Tapsell LC, Williams PG, Gordon M. Plant sterols as dietary adjuvants in the reduction of cardiovascular risk: theory and evidence. Vasc Health Risk Manag. 2006;2:157–62.PubMedCrossRefGoogle Scholar
  52. Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005; 289:R771–5.PubMedCrossRefGoogle Scholar
  53. Pérez YY, Jiménez-Ferrer E, Zamilpa A, Hernández-Valencia M, Alarcón-Aguilar FJ, Tortoriello J, Román-Ramos R. Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. Am J Chin Med. 2007;35:1037–46.PubMedCrossRefGoogle Scholar
  54. Prasain JK, Jones K, Kirk M, Wilson L, Smith-Johnson M, Weaver C, Barnes S. Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J Agric Food Chem. 2003;51: 4213–8.PubMedCrossRefGoogle Scholar
  55. Riba J, Valle M, Urbano G, Yritia M, Morte A, Barbanoj MJ. Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. J Pharmacol Exp Ther. 2003;306: 73–83.PubMedCrossRefGoogle Scholar
  56. Rooke N, Li DJ, Li J, Keung WM. The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin. J Med Chem. 2000;43:4169–79.PubMedCrossRefGoogle Scholar
  57. Sadovsky R, Collins N, Tighe AP, Brunton SA, Safeer R. Patient use of dietary supplements: a clinician’s perspective. Curr Med Res Opin. 2008;24:1209–16.PubMedCrossRefGoogle Scholar
  58. Sahin K, Onderci M, Tuzcu M, Ustundag B, Cikim G, Ozercan IH, Sriramoju V, Juturu V, Komorowski JR. Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism. 2007;56:1233–40.PubMedCrossRefGoogle Scholar
  59. Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol. 2007;3:360–6.PubMedCrossRefGoogle Scholar
  60. Schwarz E, Metzler J, Diedrich JP, Freudenstein J, Bode C, Bode JC. Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: results of a double-blind, placebo-controlled crossover study. J Immunother. 2002;25:413–20.PubMedCrossRefGoogle Scholar
  61. Schwarz O, Jakupovic S, Ambrosi HD, Haustedt LO, Mang C, Müller-Kuhrt L. Natural products in parallel chemistry-novel 5-lipoxygenase inhibitors from BIOS-based libraries starting from alpha-santonin. J Comb Chem. 2007;9: 1104–13.PubMedCrossRefGoogle Scholar
  62. Seren S, Lieberman R, Bayraktar UD, Heath E, Sahin K, Andic F, Kucuk O. Lycopene in cancer prevention and treatment. Am J Ther. 2008;15:66–81.PubMedCrossRefGoogle Scholar
  63. Shih CC, Lin CH, Lin WL. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract. 2008 June 10 [Epub ahead of print]Google Scholar
  64. Strimpakos AS, Sharma RA. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal. 2008;10:511–45.PubMedCrossRefGoogle Scholar
  65. Turnbull D, Whittaker MH, Frankos VH, Jonker D. 13-week oral toxicity study with stanol esters in rats. Regul Toxicol Pharmacol. 1999;29: 216–26.PubMedCrossRefGoogle Scholar
  66. Ulrich-Merzenich G, Zeitler H, Jobst D, Panek D, Vetter H, Wagner H. Application of the “-Omic-” technologies in phytomedicine. Phytomedicine. 2007;14:70–82.PubMedCrossRefGoogle Scholar
  67. van Breemen RB, Fong HH, Farnsworth NR. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008;87:509S–13S.PubMedGoogle Scholar
  68. Vijayakumar MV, Bhat MK. Hypoglycemic effect of a novel dialysed fenugreek seeds extract is sustainable and is mediated, in part, by the activation of hepatic enzymes. Phytother Res. 2008;22:500–5.PubMedCrossRefGoogle Scholar
  69. Watkins SM, German JB. Toward the implementation of metabolomic assessments of human health and nutrition. Curr Opin Biotechnol. 2002: 13:512–6.PubMedCrossRefGoogle Scholar
  70. Whitsett T, Carpenter M, Lamartiniere CA. Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats. J Carcinog. 2006;5:15.PubMedCrossRefGoogle Scholar
  71. Xu S, Levine M. Medical residents’ and students’ attitudes towards herbal medicines: a pilot study. Can J Clin Pharmacol. 2008;15:e1–4.PubMedGoogle Scholar
  72. Yang XX, Hu ZP, Duan W, Zhu YZ, Zhou SF. Drug-herb interactions: eliminating toxicity with hard drug design. Curr Pharm Des. 2006;12:4649–64.PubMedCrossRefGoogle Scholar
  73. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabet Care. 2003;26:1277–94.CrossRefGoogle Scholar
  74. Zhang HG, Kim H, Liu C, Yu S, Wang J, Grizzle WE, Kimberly RP, Barnes S. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochim Biophys Acta. 2007;1773:1116–23.PubMedCrossRefGoogle Scholar
  75. Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, Kohut ML, Cunnick JE. Enhancement of innate and adaptive immune functions by multiple Echinacea species. J Med Food. 2007;10:423–34.PubMedCrossRefGoogle Scholar
  76. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45–53.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyBirminghamUSA
  2. 2.University of Alabama at BirminghamPurdue University-University of Alabama, Botanicals Center for Age-Related DiseaseBirminghamUSA
  3. 3.Center for Nutrient-Gene InteractionBirminghamUSA
  4. 4.Department of Pharmacology and ToxicologyRoom 452, McCallum Research Building. University of Alabama at Birmingham, 1918 University BoulevardBirminghamUSA

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