Abstract
Biomaterials, be they metal or polymer, ceramic or glass or some combination of all of these, when placed inside the human body are not normally rejected. The term rejection in this context generally refers to an adverse immunological response analogous to that seen when patients reject an organ transplant. For the most part, non-biological materials when placed in contact with human tissue, either upon or beneath the skin are well tolerated and may become “accepted” by the body. In these circumstances, if the implant is then able to effectively carry out its function for the required period of time, it may be described as expressing biocompatibility.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pawlowski KJ. Host reactions, in Bowlin GL, ed. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Dekker: New York, 2004, pp. 770–778.
Anderson JM. Inflammation, wound healing and the foreign body response, in Ratner BD, Hoffman AS, Schoen FJ, and Lemons JE, eds. Biomaterials Science: An Introduction to Materials in Medicine, 2nd edn, Elsevier: Amsterdam, 2004, pp. 296–303.
Williams DF. The Williams Dictionary of Biomaterials, University of Liverpool Press: Liverpool, 1999.
Hunt JA. Foreign body response, in Bowlin GL, ed. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Dekker: New York, 2004, pp. 641–648.
Kopp R, Mottaghy K, and Kirschfink M. Mechanism of complement activation during extracorporeal blood-biomaterial interaction: effects of heparin coated and uncoated surfaces. ASAIO, 2002, 48: 598–605.
Costerton B, Cook G, Shirtliff M, Stoodley P, and Pasmore M. Biofilms, biomaterials and device-related infections, in Ratner BD, Hoffman AS, Schoen FJ, and Lemons JE, eds. Biomaterials Science: An Introduction to Materials in Medicine, 2nd edn, Elsevier: Amsterdam, 2004, pp. 345–354.
Roberts WE. Bone tissue interface. J Dent Educ, 1988, 52: 804–809.
Hanson SR. Blood-material interactions, in Bowlin GL, ed. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Dekker: New York, 2004, pp. 144–154.
Williams DF, ed. Definitions in biomaterials, in Progress in Biomedical Engineering, vol. 4, Elsevier: Amsterdam, 1987, p. 54.
Williams DF. Biocompatibility, an overview, in Williams DF, ed. Concise Encyclopedia of Medical and Dental Materials, Pergammon Press: New York, 1990, pp. 51–59.
Chauval-Lebret DJ, Auroy P, Tricot-Doleux S, and Bonnaure-Mallet M. Evaluation of the SCGE assay to assess the genotoxicity of biomaterials. Biomaterials, 2001, 22: 1795–1807.
ISO 10993. The Biological Evaluation of Medical Devices, Part 4: Selection of Tests for Interactions with Blood, International Standard Organization 2002, pp. 10993–10994.
Renvoize C, Biola A, Pallardy M, and Breard J. Apoptosis; identification of dying cells. Cell Biol Toxicol, 1998, 14: 111–120.
Jones B and Stacey G. Safety considerations for in vitro toxicology testing. Cell Biol Toxicol, 2001, 17: 247–270.
ISO 10993. The Biological Evaluation of Medical Devices, Part 5: Tests for Toxicity; In Vitro Methods, International Standard Organization 2002, pp. 10993–10995.
Pizzoferatto A, Ciapetti G, Stea S, Cenni E, Arciola CR, Grachi D, and Savarino L. Cell culture methods for testing biocompatibility. Clin Mater, 1994, 15: 173–190.
Kirkpatrick CJ, Bittinger F, Wagner M, Kohler H, van Kooten TG, Klein CL, and Otto M. Current trends in biocompatibility testing. Proc Inst Mech Eng, 1998, 212: 75–84.
Doherty PJ. Cell culture assays, in Bowlin GL, ed. Encyclopedia of Biomaterials and Biomedical Engineering, Marcel Dekker: New York, 2004, pp. 292–298.
BS EN ISO 10993-3. Biological evaluation of medical devices, Part 3: Tests for genotoxicity, carcinogenicity and reproductive toxicity, 2003.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Doherty, P. (2009). Inflammation, Carcinogenicity and Hypersensitivity. In: Narayan, R. (eds) Biomedical Materials. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84872-3_7
Download citation
DOI: https://doi.org/10.1007/978-0-387-84872-3_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-84871-6
Online ISBN: 978-0-387-84872-3
eBook Packages: EngineeringEngineering (R0)