Bioinformatics Analysis: Gene Fusion

  • Meena Kishore Sakharkar
  • Yiting Yu
  • Pandjassarame Kangueane


Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.


Fusion Protein Lateral Gene Transfer Fusion Event Fusion Partner Mycobacterium Smegmatis 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Meena Kishore Sakharkar
    • 1
  • Yiting Yu
    • 1
  • Pandjassarame Kangueane
    • 2
  1. 1.Nanyang Technology UniversitySingapore
  2. 2.Biomedical InformaticsIndia

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