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Chromium in Cancer and Dietary Supplements

  • Aviva Levina
  • Rachel Codd
  • Peter A. Lay
Chapter
Part of the Biological Magnetic Resonance book series (BIMR, volume 28)

For many years, the carcinogenicity of Cr(VI) and the antidiabetic effects of Cr(III) compounds were regarded as independent biological activities, but recent evidence suggests that both these types of activities arise from varying amounts of Cr(VI) and reactive intermediates, such as Cr(V) species, which can be formed in vivo either by reduction of Cr(VI) or by oxidation of Cr(III) complexes. Applications of EPR spectroscopy for the studies of Cr(V) and other reactive intermediates of relevance to the biological activities of Cr(VI) and Cr(III) compounds have been reviewed. Due to the d1 electronic structure of Cr(V) complexes, EPR spectroscopy can be used as a highly sensitive and selective tool for the detection of Cr(V) intermediates formed in biological systems exposed to Cr(VI) (and potentially to Cr(III) complexes). Applications of EPR spectroscopy for the studies of Cr(V) and other reactive intermediates of relevance to the biological activities of Cr(VI) and Cr(III) compounds have been reviewed.

Keywords

Electron Paramagnetic Resonance Dietary Supplement Spin Trap Amino Acid Complex Benzohydroxamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York 2009

Authors and Affiliations

  1. 1.Centre for Heavy Metals Research and Centre for Structural Biology and Structural Chemistry, School of Chemistry, The University of SydneySydneyAustralia

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