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Interleukin-2 and Septohippocampal Neurons: Neurodevelopment and Autoimmunity

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The Neuroimmunological Basis of Behavior and Mental Disorders

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Abstract

As is the case for IL-2’s biology in the peripheral immune system, the effects of IL-2 on brain development, function and disease also appear to be bidirectional and highly complex. Determining whether, and under what circumstances (e.g., development, acute injury) these different actions of IL-2 are operative in the brain is essential to make significant advances in understanding the multifaceted affects of IL-2 on CNS function and disease. Good animal models such as our IL-2 knockout mouse model could provide valuable new insight into how this cytokine may have simultaneous, dynamics effects on multiple systems (e.g., regulating homeostasis in the brain and immune system, autoimmunity that can affect both systems). This chapter presents some of our research and synthesizes the relevant literature in an attempt to understand better the complex actions IL-2 on septohippocampal neurons, and how this cytokine may influence brain neurodevelopment and autoimmunity. Such information may provide new insight into the role of brain cytokines and autoimmunity in prominent neurological and neuropsychiatric diseases (e.g., multiple sclerosis, Alzheimer’s disease, schizophrenia).

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Authors and Affiliations

  1. Departments of Psychiatry, Neuroscience, and Pharmacology & Therapeutics, McKnight Brain Institute, FL, USA

    John M. Petitto

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  1. John M. Petitto
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  2. Zhi Huang
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  3. Grace K. Ha
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  1. Departments of Neurology and Neuroscience and Psychiatry, University of Medicine and Dentistry of New Jersey — NJ Medical School, Newark, NJ 07103, USA

    Allan Siegel

  2. University of Medicine and Dentistry of New Jersey — NJ Medical School, Newark, NJ 07103, USA

    Steven S. Zalcman

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Petitto, J.M., Huang, Z., Ha, G.K., Dauer, D. (2009). Interleukin-2 and Septohippocampal Neurons: Neurodevelopment and Autoimmunity. In: Siegel, A., Zalcman, S.S. (eds) The Neuroimmunological Basis of Behavior and Mental Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84851-8_8

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