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Immunity and Depression: A Clinical Perspective

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The Neuroimmunological Basis of Behavior and Mental Disorders

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Abstract

Depressive disorders, among the most common of human ailments, are a major public health challenge, including increased risk for somatic diseases. This chapter summarizes the complex observations suggesting an immune component for such medical morbidity as a consequence of two broad categories of immune change: decreased immune functions and increased inflammation. Reciprocal effects of the immune system, especially inflammation, on brain and behavior, suggest that some psychiatric disorders, including depression, may be immunologically mediated in part.

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  1. Department of Psychiatry, UMDNJ–NJ Medical School, Behavioral Health Science Building Room F-1430 183 South Orange Avenue, Newark, NJ 07103, USA

    Steven J. Schleifer

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  1. Departments of Neurology and Neuroscience and Psychiatry, University of Medicine and Dentistry of New Jersey — NJ Medical School, Newark, NJ 07103, USA

    Allan Siegel

  2. University of Medicine and Dentistry of New Jersey — NJ Medical School, Newark, NJ 07103, USA

    Steven S. Zalcman

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Schleifer, S.J. (2009). Immunity and Depression: A Clinical Perspective. In: Siegel, A., Zalcman, S.S. (eds) The Neuroimmunological Basis of Behavior and Mental Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84851-8_14

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