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Other Model Organisms for Sarcomeric Muscle Diseases

  • John Sparrow
  • Simon M. Hughes
  • Laurent Segalat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 642)

Abstract

Model organisms are vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism are outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.

Keywords

Duchenne Muscular Dystrophy Myosin Heavy Chain Muscle Development Duchenne Muscular Dystrophy Muscle Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • John Sparrow
    • 1
  • Simon M. Hughes
    • 2
    • 3
  • Laurent Segalat
    • 4
  1. 1.Department of BiologyUniversity of YorkYorkUK
  2. 2.Randall Division of Cell and Molecular BiophysicsKing’s College LondonLondonUK
  3. 3.MRC Centre for Developmental NeurobiologyKing’s College LondonLondonUK
  4. 4.Batiment MendelUniversite Claude Bernard Lyon-1VilleurbanneFrance

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